Gentamicin Bladder Instillations to Prevent Urinary Tract Infections in Patients With Spinal Cord Injury

Inclusion Criteria:

- Provision of signed and dated informed consent form.

- History of traumatic spinal cord injury (SCI) or non-traumatic spinal cord disease,
(SCD) with sustained neurological dysfunction

- At least 6 months post-initial hospital discharge following SCI/SCD onset

- Neurogenic bladder

- Ability to perform daily instillation on self or with help of others and willingness
to adhere to the study regiment.

- History of at least 2 documented urinary tract infection (UTI) during the previous 6
months (prior to screening)

- Have a designated physician or health care provider for routine care

- Use of clean intermittent catheterization or catheterization through a stoma (i.e.
Mitrofanoff) as their primary method of bladder management

Exclusion Criteria:

- Concurrent use of systemic oral or intravesical antibiotic prophylaxis

- Documented or self-reported history of gentamicin allergy

- Female patients who are currently pregnant or attempting to become pregnant

- Patients with a history of 8th cranial nerve disorder

- Co-morbidities like cancer and chronic disease that could impact patient safety OR
significantly affect the rate of UTIs and/or quality of life (QOL) substantially

- Urological co-morbidities like bladder cancer and history of kidney disease.

- Current UTI at baseline visit (assessed via urine analysis and culture and symptoms)

- Concurrent enrollment in a similar clinical trial

- Concurrent use of contraindicated diuretics (ethacrynic acid, furosemide)

- Current use of other contraindicated or disallowed concomitant medications or
receiving treatments that may influence the results from this study.

- Known allergy to aminoglycoside antibiotics

- At the discretion of study team, individuals who are unable or unlikely to comply with
procedures and/or for whom study participation is not recommended (e.g. unable to
arrange transportation, cognitive and/or behavioral challenges that preclude
meaningful participation, poor health, etc.)