Anemia Studies in Chronic Kidney Disease (CKD): Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor (PHI) Daprodustat-Three-times Weekly Dosing in Dialysis (ASCEND-TD)

Inclusion Criteria:

- Subject must be 18 to 99 years of age inclusive, at the time of signing the informed
consent.

- Use of any approved rhEPO or analog for at least 8 weeks prior to the screening visit
and continuing during the screening period until randomization (Day 1).

- Hgb concentration (measured by HemoCue) within the following range: Week -4: Hgb 8 to
11.5 grams/deciliter (5 to 7.1 millimoles/liter). If Hgb is 11.6 to 11.9
grams/deciliter (7.2 to 7.4 millimoles/liter), up to two retests are allowed; the
retest value must be between 8 to 11.5 grams/deciliter (5 to 7.1 millimoles/liter).
Day 1: Hgb 8 to 11 grams/deciliter (5 to 6.8 millimoles/liter) and receiving at least
the minimum rhEPO or analog dose 3. Hgb>11 to 11.5 grams/deciliter (6.8 to 7.1
millimoles/liter) and receiving greater than the minimum rhEPO or analog dose 3.

- On hemodialysis (including hemofiltration or hemodiafiltration) >90 days prior to
screening and continuing during the screening period.

- On hemodialysis (in-center) >=3 times per week.

- Male and female subjects are eligible. A female subject is eligible to participate if
she is not pregnant, not breastfeeding, and at least one of the following conditions
applies: Not a woman of childbearing potential (WOCBP), or A WOCBP who agrees to
follow the contraceptive guidance from at least 28 days prior to first dose of study
treatment and for at least 28 days after the last dose of study treatment.

- Capable of giving signed informed consent.

- In France, a subject will be eligible for inclusion in this study if he or she is
either affiliated to or beneficiary of a social security category.

Exclusion Criteria:

- Planned living-related or living-unrelated kidney transplant within 52 weeks after
randomization (Day 1).

- Ferritin: <=100 nanograms/milliliter (<=100 micrograms/liter), at screening.

- Transferrin saturation (TSAT): <=20 percent, at screening. If TSAT is 18 to 20
percent, then a retest using a new blood sample can be obtained within 7 days of the
final laboratory report; the final retest value must be >20 percent to confirm
eligibility.

- Aplasias: History of bone marrow aplasia or pure red cell aplasia.

- Conditions, other than anemia of CKD, which can affect erythropoiesis.

- Myocardial infarction (MI) or acute coronary syndrome within 8 weeks prior to
screening through to randomization (Day 1).

- Stroke or transient ischemic attack within 8 weeks prior to screening through to
randomization (Day 1).

- Heart failure (HF): Chronic Class IV HF, as defined by the New York Heart Association
(NYHA) functional classification system.

- Current uncontrolled hypertension as determined by the investigator that would
contraindicate the use of rhEPO.

- Bazett's correction of QTc interval (QTcB): at Day 1: QTcB >500 milliseconds, or QTcB
>530 milliseconds in subjects with bundle branch block. There is no QTc (corrected QT)
exclusion for subjects with a predominantly ventricular paced rhythm.

- Liver Disease: presence of any one of the following liver-related laboratory values or
conditions, at screening, is exclusionary: ALT >2x upper limit of normal (ULN);
Bilirubin >1.5x ULN; or Current unstable liver or biliary disease per investigator
assessment, generally defined by the presence of ascites, encephalopathy,
coagulopathy, hypoalbuminemia, esophageal or gastric varices, persistent jaundice, or
cirrhosis.

- Evidence of actively bleeding gastric, duodenal or esophageal ulcer disease OR
clinically significant gastro intestinal bleeding <= 8 weeks prior to screening
through to randomization (Day 1).

- History of malignancy within 2 years prior to screening through to randomization (Day
1), currently receiving treatment for cancer, or complex kidney cyst (e.g., Bosniak
Category IIF, III or IV) >3 centimeters.

- Use of a strong inhibitor of Cytochrome P4502C8 [CYP2C8] (e.g. gemfibrozil) or a
strong inducer of CYP2C8 (e.g. rifampin/rifampicin).

- History of severe allergic or anaphylactic reactions or hypersensitivity to excipients
in the investigational product (daprodustat) or epoetin alfa.

- Use of another investigational agent within 30 days or within five half-lives of the
investigational agent (whichever is longer) or currently participating in a study of
an investigational device prior to screening through to randomization (Day 1).

- Any prior treatment with daprodustat for treatment duration of >30 days.

- Any other condition, clinical or laboratory abnormality, or examination finding that
the investigator considers would put the subject at unacceptable risk, which may
affect study compliance (e.g. intolerance to rhEPO) or prevent understanding of the
aims or investigational procedures or possible consequences of the study.