Acetaminophen Versus IV Hydromorphone for Pain in the Elderly in the ED
| Status: | Recruiting |
|---|---|
| Conditions: | Chronic Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 65 - Any |
| Updated: | 9/2/2018 |
| Start Date: | August 20, 2018 |
| End Date: | August 1, 2019 |
| Contact: | Alexander V Latev, MD |
| Email: | alatev@montefiore.org |
| Phone: | 4254437245 |
An ED-based Randomized Trial of IV Acetaminophen Versus IV Hydromorphone for Elderly Adults With Acute Severe Pain
Intravenous opioids are the mainstay of acute, severe pain treatment in Emergency Departments
(ED) across the country. Acetaminophen, given orally, has also been used for treatment of
mild to moderate pain. The more potent intravenous (IV) form of acetaminophen has been widely
used in Europe for more than 20 years as post-surgical analgesia and received full FDA
approval in the USA in 2010. As part of a continuing set of studies whose goal is to optimize
treatment of pain among elderly ED patients, this randomized study will compare efficacy and
safety of IV acetaminophen to IV hydromorphone.
(ED) across the country. Acetaminophen, given orally, has also been used for treatment of
mild to moderate pain. The more potent intravenous (IV) form of acetaminophen has been widely
used in Europe for more than 20 years as post-surgical analgesia and received full FDA
approval in the USA in 2010. As part of a continuing set of studies whose goal is to optimize
treatment of pain among elderly ED patients, this randomized study will compare efficacy and
safety of IV acetaminophen to IV hydromorphone.
Inclusion Criteria:
1. Age equal to 65 or greater
2. Pain onset within 7 days with severe pain
3. Has capacity to provide informed consent
4. Understanding English or Spanish
Exclusion Criteria:
1. Use of tramadol or opioids within 7 days
2. Use of acetaminophen or non-steroidal anti-inflammatory medications within 8 hours
3. Chronic pain syndrome: daily pain for > 3 months. Sickle cell anemia, osteoarthritis,
fibromyalgia, and peripheral neuropathies
4. Conditions which may affect acetaminophen or opioid metabolism such as cirrhosis
(Child Pugh A or worse), kidney impairment (CKD 3 or worse), active hepatic disease or
severe dehydration
5. Alcohol intoxication
6. Systolic blood pressure: < 100 mmHg
7. Heart rate: < 60 beats per minute
8. Oxygen saturation: < 95% on room air
9. Use of monoamine oxidase (MAO) inhibitors in the past 30 days
10. Use of transdermal pain patch or oral opioid > 10 days in the prior month
11. Prior enrollment in the same study
We found this trial at
1
site
3550 Jerome Avenue
Bronx, New York 10467
Bronx, New York 10467
(718) 920-4321
Phone: 718-920-6626
Montefiore Medical Center As the academic medical center and University Hospital for Albert Einstein College...
Click here to add this to my saved trials
