Early Intrapleural TPA Instillation Versus Late
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 18 - 100 |
| Updated: | 9/5/2018 |
| Start Date: | February 17, 2017 |
| End Date: | February 16, 2020 |
| Contact: | Rohan Mankikar, MD |
| Email: | rohan.mankikar@palmettohealth.org |
| Phone: | 803-799-5022 |
Chest tubes are used for air or fluid removal from the pleural space. When a chest tube is
placed, it can be hard for the fluid to drain.Tissue plasminogen activator (tPA) and DNase
are given through the chest tube to help with draining the fluid. We are doing this research
to see if early addition of tPA-DNase immediately after chest tube placement will help with
better fluid draining.
placed, it can be hard for the fluid to drain.Tissue plasminogen activator (tPA) and DNase
are given through the chest tube to help with draining the fluid. We are doing this research
to see if early addition of tPA-DNase immediately after chest tube placement will help with
better fluid draining.
The purpose of this study is to determine the timing and efficacy of early administration and
late administration of t-PA/DNase via thoracostomy (n=60). Patients will be identified from
the Intensive Care Unit, Coronary Care Unit, and wards/stepdown units. Prior to chest tube
placement, patients will be randomized to one of the two treatment arms (early use of
t-PA-DNase verus late use of t-PA-DNase). Route of administration will be via their
thoracostomy tube over a period of three days twice daily.
late administration of t-PA/DNase via thoracostomy (n=60). Patients will be identified from
the Intensive Care Unit, Coronary Care Unit, and wards/stepdown units. Prior to chest tube
placement, patients will be randomized to one of the two treatment arms (early use of
t-PA-DNase verus late use of t-PA-DNase). Route of administration will be via their
thoracostomy tube over a period of three days twice daily.
Inclusion Criteria:
- Adult patients, age 18 years or older
- Patients with an indication for a thoracostomy tube placement for a pleural effusion
Exclusion Criteria:
- Patients that require a thoracostomy tube for a pneumothorax
- Pregnant women
- Sensitivity to t-PA, or DNase
- Patients taking carbamazepine or nitroglycerin
- Lung volume reduction surgery on side of pleural effusion
We found this trial at
1
site
Palmetto Health Richland Palmetto Health Richland, originally founded in 1892 as Columbia Hospital, has a...
Click here to add this to my saved trials
