Reduction of Pro-Inflammatory Synovial Fluid Biomarkers in Osteoarthritis of the Knee With Alpha-2 Macroglobulin

The purpose of the current study is to assess the ability of alpha-2-macroglobulin treatment
to reduce the level of pro-inflammatory synovial fluid biomarkers in patients with
osteoarthritis of the knee.

This is a double-blinded rationalized control trial with prospective data collection. The
study will collect and analyze the synovial fluid, serum, and urine of patients presenting
with knee osteoarthritis in Kellegren-Lawrence grade 2 or 3. It will compare synovial fluid
biomarker levels between patients receiving an intra-articular alpha-macroglobulin,
intra-articular PR injection and intra-articular corticosteroid serving as a control.
Pre-injection pain and function will be assessed. Post-injection pain, function and outcomes
will be assessed after six weeks and three months.