Data Visualization of Kidney and Prostate Tumors Using Routine Pre-Operative Imaging, 3D Printed, and 3D Virtual Reality Models

This early phase I trial studies how well indwelling pleural catheters with doxycycline work
compared to indwelling pleural catheters alone in treating participants with malignant
pleural effusions. These types of catheters are commonly used to treat pleural effusions
(build-up of fluid in the lungs). Doxycycline is an antibiotic that is also used to treat
pleural effusions. It is not yet known whether giving doxycycline with indwelling pleural
catheters works better than indwelling pleural catheters alone in treating participants with
cancerous pleural effusions.

Inclusion Criteria:

- Outpatients with MPE undergoing IPC placement

- Sufficient mental capacity to provide informed consent and answer Short-Form
Six-Dimension health index (SF-6D) and Borg score questions

Exclusion Criteria:

- Patients undergoing pleurodesis for benign disease (e.g., spontaneous pneumothorax)

- Inability or unwillingness to give informed consent

- Inability to perform phone call and clinical follow-up at MD Anderson Cancer Center
(MDACC)

- Pregnancy

- Previous intrapleural therapy for MPE on the same side

- Eastern Cooperative Oncology Group (ECOG) of 4 and life expectancy ≤ 2 weeks

- Doxycycline allergy

- Extensive loculations or hydropneumothorax or other contraindication to pleurodesis

- Chylous effusions associated with malignant disease