Hematologic Ratios in Postoperative Acute Kidney Injury

In adults, hematological ratios which can be calculated from a routinely ordered complete
blood count with differential, such as the neutrophil/lymphocyte ratio, have been
demonstrated to be correlated with acute kidney injury (AKI) and other clinical outcomes
after cardiovascular surgery. In this retrospective observational study, the association
between hematological ratios (neutrophil/lymphocyte ratio, platelet/lymphocyte ratio,
neutrophil/lymphocyte*platelet ratio, monocyte/lymphocyte ratio, and plateletcrit) and
postoperative AKI, morbidity (length of ICU stay, hospital stay, mechanical ventilation,
vasoactive infusion-free days, etc.) and mortality will be evaluated in neonates who
underwent cardiac surgery with cardiopulmonary bypass.

Inclusion Criteria:

- Neonates (≤31 days) who underwent cardiac surgery with cardiopulmonary bypass for
congenital heart disease.

Exclusion Criteria:

- Patients with missing relevant preoperative or postoperative data points

- Patients with previous palliation or reoperation,

- Thymus hypo/aplasia (DiGeorge Syndrome, Ataxia-telangiectasia, or Nezelof syndrome),

- Primary immunodeficiency,

- Episode of cardiac arrest within 1 week before surgery,

- Signs or history of preoperative renal impairment or AKI (KDIGO Stage ≥1 observed on
preoperative labs),

- Hypothyroidism,

- Patients with a history of infection within a week prior to surgery or antibiotics
administered within the first 3 days after surgery (except for postoperative
antibiotics).