[C-11]NOP-1A and Alcohol Use Disorder

This will allow for understanding brain stress and antistress mechanisms that underlie abuse
of alcohol in humans

[A] Alcohol use disorders (AUD)

Inclusion Criteria:

1. Males or Females

2. Fulfill DSM5 diagnosis for alcohol use disorder

3. Medically Healthy

Exclusion Criteria:

1. Pregnancy or lactation

2. Comorbid severe/major medical, psychiatric (such as bipolar and psychotic disorders,
etc.,) and current comorbid drug use disorders (other than tobacco use and
recreational marijuana use)

3. Metal implants or paramagnetic objects contained within the body which may interfere
with MRI scans

4. Currently employed as a radiation worker, or participation in radiation drug research
procedures within the previous year

5. Currently on any psychotropic medications that can influence nociceptin transmission
in the brain

[B]Healthy controls

Inclusion Criteria:

1. Males or females

2. Absence of present or past psychiatric conditions (including alcohol or drug use
disorders)

3. Medically Healthy

Exclusion Criteria:

1. Pregnancy of lactation

2. Medical, psychiatric or comorbid drug/alcohol use disorders

3. Metal implants or paramagnetic objects contained within the body which may interfere
with the MRI scan

4. Currently employed as a radiation worker; or participation in radioactive drug
research protocols within the previous year

5. Currently on any psychotropic medications that can influence nociceptin transmission
in the brain

6. Family history of psychotic disorder, manic episode, drug and alcohol use disorder in
first-degree relatives