An Investigational Immunotherapy Study of BMS-986310 Administered Alone and in Combination With Nivolumab in Patients With Advanced Solid Tumors

Inclusion Criteria:

- Patients with measurable disease per RECIST v1.1 and have at least one lesion
accessible for biopsy.

- ECOG performance status less than or equal to 1

Part 1 and Sub-study B:

i) Part 1 participants must have advanced or metastatic disease where no other standard of
care treatment option is possible.

ii) Sub-study B participants must have advanced or metastatic disease where no other
standard of care treatment is possible, and they must have had disease progression on an
anti-PD-(L)1 based regimen as their most recent prior therapy

Sub-study A:

i) Males and females with histologically confirmed TNBC as defined by ASCO/CAP guidelines.

ii) Participants must be newly diagnosed, no prior history of treatment for TNBC.

iii) Tumor size greater than or equal to 1cm3 iv) Participants must not meet criteria for
standard of care neoadjuvant therapy and must be candidates for SOC surgical resection of
primary tumor.

Part 2 i) Patients with NSCLC ii) Patients with Pancreatic Cancer iii) Patients with TNBC
iiii) Patients with CRC

Exclusion Criteria:

- History of severe adverse drug reactions to nonsteroidal anti-inflammatory drugs
(NSAIDs), or those with adverse reactions to an NSAID that is currently prescribed

- Participants with an active, known or suspected autoimmune disease.