Pulmonary Arterial Hypertension Secondary to Idiopathic Pulmonary Fibrosis and Treatment With Bosentan
| Status: | Withdrawn |
|---|---|
| Conditions: | High Blood Pressure (Hypertension), Pulmonary |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 4/17/2018 |
| Start Date: | October 2007 |
| End Date: | December 2009 |
Treatment of Pulmonary Arterial Hypertension Secondary to Idiopathic Pulmonary Hypertension With Bosentan: A Single Center Pilot Study
Pulmonary Arterial Hypertension (PAH) in the setting of Idiopathic Pulmonary Fibrosis(IPF)is
a risk factor for morbidity and mortality in the peri-lung transplant(LT) setting. Currently
there is no significant data to support the use of pulmonary vasodilators for PAH in the
setting of interstitial lung disease such as IPF. The majority of IPF patients have PAH
either at rest or during exercise. The study hypothesis is that bosentan may improve
morbidity and mortality in the peri-LT setting in both IPF cohorts with either resting or
exercise PAH.
a risk factor for morbidity and mortality in the peri-lung transplant(LT) setting. Currently
there is no significant data to support the use of pulmonary vasodilators for PAH in the
setting of interstitial lung disease such as IPF. The majority of IPF patients have PAH
either at rest or during exercise. The study hypothesis is that bosentan may improve
morbidity and mortality in the peri-LT setting in both IPF cohorts with either resting or
exercise PAH.
The purpose of this study was to evaluate bosentan in the setting of exercise or resting
pulmonary hypertension in patients with underlying pulmonary fibrosis.
pulmonary hypertension in patients with underlying pulmonary fibrosis.
Inclusion Criteria:
- Idiopathic Pulmonary Fibrosis referred for lung transplantation
- Minimum 50 meter 6 minute walk distance
- No significant underlying liver disease
Exclusion Criteria:
- Significant liver disease or cirrhosis
- non ambulatory
- previous adverse reaction/allergy to Bosentan
We found this trial at
2
sites
Los Angeles, California 90095
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10833 Le Conte Ave
Los Angeles, California 90095
Los Angeles, California 90095
(310) 825-4321
David Geffen School of Medicine, UCLA In 2002 Mr. David Geffen announced a $200 million...
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