Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity

Inclusion Criteria: - Male or female, age greater than or equal to 45 years at the time of
signing informed consent - Body mass index (BMI) greater than or equal to 27 kg/m^2 - Have
established cardiovascular (CV) disease as evidenced by at least one of the following:
prior myocardial infarction; prior stroke (ischemic or haemorrhagic stroke); or symptomatic
peripheral arterial disease (PAD), as evidenced by intermittent claudication with
ankle-brachial index (ABI) less than 0.85 (at rest), or peripheral arterial
revascularization procedure, or amputation due to atherosclerotic disease Exclusion
Criteria: - Any of the following: myocardial infarction, stroke, hospitalisation for
unstable angina pectoris or transient ischaemic attack within the past 60 days prior to the
day of screening - HbA1c greater than or equal to 48 mmol/mol (6.5 %) as measured by the
central laboratory at screening - History of type 1 or type 2 diabetes (history of
gestational diabetes is allowed)