A Prospective Observational Study of TPIAT

Patients who are undergoing TPIAT at one of the participating center are invited to
participate in this observational study, with 450 participants anticipated. The aims of the
study are:

Aim 1: To determine (1a) whether patient and disease characteristics are associated with
favorable pain and health-related quality-of-life outcomes (HRQOL) after TPIAT; (1b) the
optimal timing of the TPIAT intervention to resolve pain and improve HRQOL; and (1c) in a
subset of patients, the impact of central sensitization on pain resolution.

Aim 2: To determine (2a) whether patient and disease characteristics are associated with
favorable glycemic outcomes from the IAT procedure; and (2b) the optimal timing of TPIAT to
obtain post-surgical insulin independence.

Aim 3: To determine the cost-effectiveness of TPIAT.

Inclusion Criteria:

1. Any patient with chronic or recurrent acute pancreatitis undergoing total or completion
pancreatectomy with islet autotransplantation at a participating center.

Exclusion Criteria:

1. Partial pancreatectomy

2. TPIAT performed for a diagnosis other than chronic or recurrent acute pancreatitis
(for example benign or malignant pancreatic tumor)