A Study to Assess the Safety and Efficacy of Brexanolone in the Treatment of Adolescent Female Subjects With Postpartum Depression

Key Inclusion Criteria:

1. Subject either has ceased lactating at screening or, if still lactating or actively
breastfeeding at screening, must agree to temporarily cease giving breastmilk to their
infants.

2. Subject has had a major depressive episode that began no earlier than the third
trimester and no later than the first 4 weeks following delivery, as diagnosed by
Structured Clinical Interview for DSM-5 Disorders (SCID-5).

3. Subject is ≤6 months postpartum at screening.

Key Exclusion Criteria:

1. Active psychosis

2. Attempted suicide during current episode of PPD

3. Medical history of bipolar disorder, schizophrenia, and/or schizoaffective disorder.

Note: Other protocol-defined inclusion/exclusion criteria may apply.