IPH5401 (Anti-C5aR) in Combination With Durvalumab in Patients With Advanced Solid Tumors

Inclusion Criteria:

1. Patients with advanced and/or metastatic histologically solid tumors with evidence of
active disease, who have been treated with a minimum of one line of systemic therapy
in the metastatic setting, and in part 2, no more than two prior systemic therapies.

2. At least 18 years of age.

3. ECOG performance status of ≤1.

4. Adequate organ function

Exclusion Criteria:

1. For patients with NSCLC:

a. Known actionnable mutation or rearrangement (including but not limited to the
epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK) gene
rearrangements, ROS-1 alterations or BRAF mutations)

2. For patient with Hepatocellular carcinoma:

1. Hepatic encephalopathy in the past 12 months.

2. Ascites that requires repeated paracentesis in the past 2 months.

3. Main portal vein thrombosis.

4. Active or prior history of gastrointestinal bleeding in the past 12 months.

5. Prior hepatic transplantation.

3. Patients with known spinal cord compression.

4. Symptomatic, untreated, or actively progressing central nervous system (CNS)
metastases.