Markers of Recovery in StrokE Study (MORSE)
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/6/2019 |
| Start Date: | October 1, 2018 |
| End Date: | August 2020 |
Markers of Recovery in StrokE Study
Our current biological understanding of stroke recovery in humans is extremely limited and
this lack of knowledge is a major challenge in reducing stroke disabilities and deficits.
Evidence of neural repair in humans can be gleaned indirectly through functional outcome
measures, but we propose that metabolomics may also provide a minimally invasive window into
human brain repair. This study will integrate clinical imaging and molecular biomarkers as a
diagnostic tool in further understanding stroke recovery mechanisms.
this lack of knowledge is a major challenge in reducing stroke disabilities and deficits.
Evidence of neural repair in humans can be gleaned indirectly through functional outcome
measures, but we propose that metabolomics may also provide a minimally invasive window into
human brain repair. This study will integrate clinical imaging and molecular biomarkers as a
diagnostic tool in further understanding stroke recovery mechanisms.
Our long-term goal is to improve and hasten recovery following a stroke with translational
research, which would combine the use of neuroimaging and identify neural repair metabolites.
The objective and sequential step in fulfilling our long-term goal, is to identify
differential expression of select stroke plasma biomarkers of neural repair, and image CST
integrity in patients with good and poor recovery following an ischemic stroke. Diffusion
tension imaging (DTI), will be used to image the neural repair as it occurs, further
enhancing our understanding of stroke recovery. There are currently no known plasma
biomarkers of neural repair. Identification of such biomarkers would be extremely valuable
for designing stroke recovery drugs and timing rehabilitation therapies.
research, which would combine the use of neuroimaging and identify neural repair metabolites.
The objective and sequential step in fulfilling our long-term goal, is to identify
differential expression of select stroke plasma biomarkers of neural repair, and image CST
integrity in patients with good and poor recovery following an ischemic stroke. Diffusion
tension imaging (DTI), will be used to image the neural repair as it occurs, further
enhancing our understanding of stroke recovery. There are currently no known plasma
biomarkers of neural repair. Identification of such biomarkers would be extremely valuable
for designing stroke recovery drugs and timing rehabilitation therapies.
Inclusion Criteria:
- Imaging confirmed ischemic stroke within 7 days of stroke onset
- Age > 18 years
- NIHSS ≥ 1 on arm item OR NIHSS = 0 on arm item but < 3/5 strength on MRC scale in
distal joint (flex/ext elbow or grip/ext hand)
- Pre-stroke modified Rankin Scale (mRS) < 3
Exclusion Criteria:
- Active malignancy (not thought to be cured or in remission)
- Anemia (HCT < 25)
- Sepsis
- Suspected bacterial endocarditis
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