Resistant Maltodextrin for Gut Microbiome in Parkinson's Disease: Safety and Tolerability Study
| Status: | Recruiting |
|---|---|
| Conditions: | Parkinsons Disease |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 60 - Any |
| Updated: | 9/14/2018 |
| Start Date: | September 10, 2018 |
| End Date: | September 30, 2019 |
| Contact: | Roneil G Malkani, MD |
| Email: | r-malkani@northwestern.edu |
| Phone: | 312-503-1350 |
Gut Microbial Remodeling With Resistant Maltodextrin for Motor and Non-motor Symptoms in Parkinson's Disease: Safety and Tolerability Study
This study will evaluate the safety and tolerability of a dietary fiber, resistant
maltodextrin, in people with Parkinson's disease. It will also evaluate the fiber's effect on
the gut microbiome and potential effects on motor function and non-motor functions. Half of
the participants will receive resistant maltodextrin and the other half will receive a
control substance, maltodextrin.
maltodextrin, in people with Parkinson's disease. It will also evaluate the fiber's effect on
the gut microbiome and potential effects on motor function and non-motor functions. Half of
the participants will receive resistant maltodextrin and the other half will receive a
control substance, maltodextrin.
Intestinal microbiota may play in important role in Parkinson's disease (PD). Colonic
bacteria play roles in multiple functions including gut motility and secretion of metabolites
which can have systemic effects on the body. Recent evidence has shown that people with PD
have an altered distribution of gut bacteria that healthy controls. These changes are
associated with differences in various metabolites, including butyrate, that are involved in
maintaining the gut barrier integrity and even gait and balance function. Microbiota
dysbiosis could potentially exacerbate or even contribute to the pathogenesis of PD.
Probiotic and dietary interventions may improve gut function and the motor symptoms in PD,
but neither have been examined for their effect on the gut microbiome. Prebiotic treatments
have been shown to order the microbiome in some populations, but have not been assessed for
tolerability or efficacy in PD.
The objective of this study is to examine the safety and tolerability of resistant
maltodextrin (RM), a prebiotic non-digestible fiber, and its effect on the microbiome and
motor in non-motor symptoms and PD. The investigators will conduct a randomized,
parallel-group double-blinded controlled trial assessing RM 50 g daily compared to
maltodextrin (an easily digestible glucose polysaccharide) over 4 weeks. Patients will be
dosed with 25 g daily for 1 week and then titrated to 50 g daily for the remaining 3 weeks.
The goals of this study include: 1) To determine the safety and tolerability of RM compared
to maltodextrin in patients with PD; 2) To determine if RM will remodel the gut microbiome in
patients with PD; 3) (exploratory) To determine if RM administration will improve motor and
non-motor symptoms in PD.
bacteria play roles in multiple functions including gut motility and secretion of metabolites
which can have systemic effects on the body. Recent evidence has shown that people with PD
have an altered distribution of gut bacteria that healthy controls. These changes are
associated with differences in various metabolites, including butyrate, that are involved in
maintaining the gut barrier integrity and even gait and balance function. Microbiota
dysbiosis could potentially exacerbate or even contribute to the pathogenesis of PD.
Probiotic and dietary interventions may improve gut function and the motor symptoms in PD,
but neither have been examined for their effect on the gut microbiome. Prebiotic treatments
have been shown to order the microbiome in some populations, but have not been assessed for
tolerability or efficacy in PD.
The objective of this study is to examine the safety and tolerability of resistant
maltodextrin (RM), a prebiotic non-digestible fiber, and its effect on the microbiome and
motor in non-motor symptoms and PD. The investigators will conduct a randomized,
parallel-group double-blinded controlled trial assessing RM 50 g daily compared to
maltodextrin (an easily digestible glucose polysaccharide) over 4 weeks. Patients will be
dosed with 25 g daily for 1 week and then titrated to 50 g daily for the remaining 3 weeks.
The goals of this study include: 1) To determine the safety and tolerability of RM compared
to maltodextrin in patients with PD; 2) To determine if RM will remodel the gut microbiome in
patients with PD; 3) (exploratory) To determine if RM administration will improve motor and
non-motor symptoms in PD.
Inclusion Criteria:
- Men and women age ≥60 years
- Diagnosis of PD based on United Kingdom PD brain bank criteria, Hoehn and Yahr stage
1-3.
- Stable dose of PD medications for 30 days prior to study and for duration of study
- If used, stable dose of melatonin, sedative/hypnotic or stimulant medications
Exclusion Criteria:
- use of other prebiotic or probiotic treatment for 30 days prior to or during the study
- unstable medical or psychiatric disorder
- history of diabetes mellitus or current use of medication for diabetes
- cognitive impairment based on Montreal Cognitive Assessment (MoCA) <25.
- current or recent (within previous 3 weeks) use of laxatives
- use of antibiotics in the past 30 days
- participation in another clinical trial in the past 30 days.
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