REsting and Stimulus-based Paradigms to Detect Organized NetworkS and Predict Emergence of Consciousness



Status:Recruiting
Conditions:Neurology, Psychiatric
Therapuetic Areas:Neurology, Psychiatry / Psychology
Healthy:No
Age Range:18 - Any
Updated:2/17/2019
Start Date:September 5, 2018
End Date:November 1, 2027
Contact:Brian L Edlow, MD
Email:bedlow@mgh.harvard.edu
Phone:6177246352

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Trial Summary
Trial Overview
Inclusion Criteria

Advanced MRI and EEG to Predict Recovery of Consciousness After Severe Traumatic Brain Injury

The aim of this study is to assess the utility of advanced magnetic resonance imaging (MRI)
and electroencephalographic (EEG) technologies for predicting functional outcomes in patients
with severe traumatic brain injury (TBI).


Patients:

Inclusion Criteria:

- Traumatic Brain Injury

- Glasgow Coma Scale score of 3-8 within 24 hours, unconfounded by sedation, paralysis,
hypoxia, hypotension, hypothermia, or concurrent medical illness

- Clinical evidence of disorder of consciousness defined as coma, VS, or MCS

Exclusion Criteria:

- History of prior severe brain injury or dementia

- Emergence from MCS at time of initial CRS-R assessment

Healthy Subjects:

Exclusion Criteria:

History of brain injury or neurological disease, psychiatric disease, or any history of
diabetes, high blood pressure, heart disease, or kidney disease
We found this trial at
1
site
Massachusetts General Hospital
185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
Phone: 617-724-6352
?
mi
from
Boston, MA
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