Acupuncture Intervention for AYA With Cancer

Acupuncture is an integrative medicine (IM) with a growing evidence base that is often
incorporated into comprehensive pain management in adult oncology. However, it is
under-utilized and under-researched in pediatric oncology, especially with adolescents and
young adults (AYA). Acupuncture is a promising palliative therapy to manage pain and improve
quality of life (QOL) of AYA. AYA are underserved and typically endure more morbidity and
longer treatments than younger patients. More than half report at least three debilitating
cancer-related symptoms and their QOL is significantly lower compared to norms, with symptoms
being the greatest contributor to poor QOL. Not surprisingly, AYA identify pain management as
an unmet need, leading a majority of AYA to want information on IM or seek it for treatment.
Given the potential benefit of acupuncture for addressing unmet needs of AYA by reducing
physical suffering, and the established difficulty with pain management using conventional
methods, there is a critical need to establish the efficacy of acupuncture for pain
management in AYA. The few studies that have evaluated acupuncture in pediatric oncology,
demonstrating it to be safe, accepted, and associated with symptom relief are uncontrolled,
retrospective, and/or unprotocolized, and none focus on AYA. To establish the evidence base
for acupuncture in AYA oncology, research is needed to determine and test optimal acupuncture
protocols.

AYA Inclusion Criteria:

- Report a pain severity score of ≥ 4 in last 7 days on an 11-point (0-10) numerical
rating scale and reports a pain distress score of ≥ 2 on a 5-point numerical rating
scale

- Males or females age 13 to 24 years

- On treatment for cancer for at least one month or within two years of completing
treatment

- Not expected to be terminal within the next 6 months

- Absence of infection or bleeding disorder

- Physically and medically able to get to the acupuncture clinic

- Able to read and write English

AYA Exclusion Criteria:

- Absence of inclusion criteria above

- Parents'guardians or subjects who, in the opinion of the investigator, may be
non-compliant with the study schedules or procedures

- Cognitive impairments that would limit AYA's ability to complete measures or to
independently care for health as determined by medical team

Parent/Guardian Inclusion Criteria:

- Be primary parent/guardian of the AYA participant

- Be able to read and write English

Parent/Guardian Exclusion Criteria:

- Cognitive impairments that would limit the parent/guardian's ability to complete
measures

- Absence of inclusion criteria above