Coffee and Real-time Atrial and Ventricular Ectopy
| Status: | Not yet recruiting |
|---|---|
| Conditions: | Women's Studies |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 12/27/2018 |
| Start Date: | February 1, 2019 |
| End Date: | December 31, 2021 |
| Contact: | Christina Fang |
| Email: | christina.fang@ucsf.edu |
| Phone: | 4154764999 |
Atrial fibrillation (AF) and heart failure (HF) are morbid, costly, and incompletely
understood diseases that have reached epidemic proportions worldwide. A dose-dependent
relationship exists between premature atrial and ventricular contractions (PACs and PVCs) and
development of AF and HF, respectively. Identifying and understanding the mechanisms of
additional modifiable risk factors for ectopy has the potential to markedly reduce the
healthcare burden of these diseases. In considering how to modify the prevalence of these
ectopic beats, the investigators believe common exposures in daily life are prime candidates.
Current guidelines suggest that caffeine may be an important trigger for frequent ectopy,
although large population-based studies have not demonstrated an association between caffeine
consumption and development of clinically significant arrhythmias. No study has employed an
actual randomization intervention to assess the effects of caffeine on cardiac ectopy.
Utilizing the Eureka platform, the investigators plan to utilize the N-of-1 strategy to
rigorously investigate the real-time effect of caffeine intake on ectopy.
understood diseases that have reached epidemic proportions worldwide. A dose-dependent
relationship exists between premature atrial and ventricular contractions (PACs and PVCs) and
development of AF and HF, respectively. Identifying and understanding the mechanisms of
additional modifiable risk factors for ectopy has the potential to markedly reduce the
healthcare burden of these diseases. In considering how to modify the prevalence of these
ectopic beats, the investigators believe common exposures in daily life are prime candidates.
Current guidelines suggest that caffeine may be an important trigger for frequent ectopy,
although large population-based studies have not demonstrated an association between caffeine
consumption and development of clinically significant arrhythmias. No study has employed an
actual randomization intervention to assess the effects of caffeine on cardiac ectopy.
Utilizing the Eureka platform, the investigators plan to utilize the N-of-1 strategy to
rigorously investigate the real-time effect of caffeine intake on ectopy.
For two weeks, participants will be asked to wear a continuously recording heart monitor and
utilize the Eureka mobile application. On the Eureka app, participants will be able to track
caffeine consumption and answer questions about mood and sleep. Participants will also
receive their randomization assignment through Eureka. Participants will be asked to modify
caffeine intake habits in two-day blocks; these assignments are either a) to consume caffeine
for one day, then avoid caffeine the next day, or b) to avoid caffeine for one day, then
consume caffeine the next day. Participants will also be given a wrist-worn fitness device
(Fitbit), to track sleep, step counts, and heart rate data.
utilize the Eureka mobile application. On the Eureka app, participants will be able to track
caffeine consumption and answer questions about mood and sleep. Participants will also
receive their randomization assignment through Eureka. Participants will be asked to modify
caffeine intake habits in two-day blocks; these assignments are either a) to consume caffeine
for one day, then avoid caffeine the next day, or b) to avoid caffeine for one day, then
consume caffeine the next day. Participants will also be given a wrist-worn fitness device
(Fitbit), to track sleep, step counts, and heart rate data.
Inclusion Criteria:
- Able to read and write in English
- Has a smartphone
- Is willing to receive message reminders from study
- Drinks caffeinated coffee or espresso drinks
- Is willing to abstain from caffeinated products when instructed
- Is willing to provide saliva sample for analysis of genetic variants related to
caffeine metabolism
Exclusion Criteria:
- Is taking an anti-arrhythmic, beta-blocker, or calcium channel blocker
- Has a pacemaker or ICD
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