Contrast-Enhanced Ultrasonography in Diagnosing Early-Stage Ovarian Cancer in Patients With an Adnexal Mass Undergoing Surgery to Remove the Ovary
Status: | Recruiting |
---|---|
Conditions: | Ovarian Cancer, Cancer |
Therapuetic Areas: | Oncology |
Healthy: | No |
Age Range: | 21 - Any |
Updated: | 4/2/2016 |
Start Date: | January 2007 |
Microvascular Perfusion Sonographic Imaging to Detect Early Stage Ovarian Cancer
RATIONALE: New diagnostic procedures, such as contrast-enhanced ultrasonography, may be an
effective method of finding ovarian cancer.
PURPOSE: This clinical trial is studying how well contrast-enhanced ultrasonography works in
diagnosing early-stage ovarian cancer in patients with an adnexal mass undergoing surgery to
remove the ovary.
effective method of finding ovarian cancer.
PURPOSE: This clinical trial is studying how well contrast-enhanced ultrasonography works in
diagnosing early-stage ovarian cancer in patients with an adnexal mass undergoing surgery to
remove the ovary.
OBJECTIVES:
- Determine whether use of a contrast agent improves the images of the ovaries during
ultrasonography.
OUTLINE: This is a multicenter study.
Patients may undergo baseline transabdominal or transvaginal ultrasonography, if not already
done. Patients then undergo contrast-enhanced transabdominal or transvaginal ultrasonography
using perflutren lipid microspheres (Definity®) IV.
Pathology reports from tissue collected during subsequent oophorectomy is analyzed and
compared with ultrasonography findings.
- Determine whether use of a contrast agent improves the images of the ovaries during
ultrasonography.
OUTLINE: This is a multicenter study.
Patients may undergo baseline transabdominal or transvaginal ultrasonography, if not already
done. Patients then undergo contrast-enhanced transabdominal or transvaginal ultrasonography
using perflutren lipid microspheres (Definity®) IV.
Pathology reports from tissue collected during subsequent oophorectomy is analyzed and
compared with ultrasonography findings.
DISEASE CHARACTERISTICS:
- Diagnosis of adnexal mass
- Scheduled to undergo surgical oophorectomy
PATIENT CHARACTERISTICS:
- Not pregnant or nursing
- Negative pregnancy test
- No known respiratory failure as manifested by signs and symptoms of carbon dioxide
retention or hypoxemia
- No pulmonary vasculitis
- No known history of severe emphysema
- No known history of pulmonary emboli
- No other condition that causes pulmonary hypertension due to compromised pulmonary
arterial vasculature
- No known history of severe pulmonary hypertension (i.e., systolic pulmonary artery
pressures > 90 mm Hg)
- No known history of congenital heart defect that creates a bidirectional or
right-to-left shunt
- No worsening or clinically unstable congestive heart failure
- No known acute myocardial infarction or acute coronary syndromes
- No known serious ventricular arrhythmias
- Not at high risk for arrhythmia due to prolongation of the QT interval
- No known or suspected hypersensitivity to blood, blood products, or albumin
- No known hypersensitivity to perflutren
- No known or suspected hypersensitivity to octafluoropropane or any other ingredients
of perflutren lipid microspheres (Definity®)
- No mental status problems, illiteracy, or other circumstance that would preclude
giving informed consent
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
We found this trial at
3
sites
Vanderbilt-Ingram Cancer Center The Vanderbilt-Ingram Cancer Center, located in Nashville, Tenn., brings together the clinical...
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324 Cool Springs Blvd
Nashville, Tennessee 37067
Nashville, Tennessee 37067
(877) 936-8422
Vanderbilt-Ingram Cancer Center - Cool Springs Vanderbilt-Ingram Cancer Center Cool Springs is a medical oncology...
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2107 Edward Curd Lane
Nashville, Tennessee 37067
Nashville, Tennessee 37067
615-591-9890
Vanderbilt-Ingram Cancer Center at Franklin The Vanderbilt-Ingram Cancer Center at Franklin is a free-standing radiation...
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