Bevacizumab and Irinotecan or Temozolomide in Treating Patients With Recurrent or Refractory Glioblastoma Multiforme or Gliosarcoma



Status:Completed
Conditions:Brain Cancer, Brain Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:9/19/2018
Start Date:March 1, 2007
End Date:February 16, 2011

Use our guide to learn which trials are right for you!

A Randomized Phase II Trial of Bevacizumab With Irinotecan or Bevacizumab With Temozolomide in Recurrent Glioblastoma

This randomized phase II trial is studying the side effects and how well giving bevacizumab
together with irinotecan or temozolomide works in treating patients with recurrent or
refractory glioblastoma multiforme or gliosarcoma. Monoclonal antibodies, such as
bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells
to grow and spread. Others find tumor cells and help kill them or carry tumor-killing
substances to them. Bevacizumab may also stop the growth of tumor cells by blocking blood
flow to the tumor. Drugs used in chemotherapy, such as irinotecan and temozolomide, work in
different ways to stop the growth of tumor cells, either by killing the cells or by stopping
them from dividing. Giving bevacizumab together with irinotecan or temozolomide may kill more
tumor cells.

PRIMARY OBJECTIVES:

I. Determine the efficacy of bevacizumab and irinotecan hydrochloride, in terms of 6-month
progression-free survival rate, in patients with recurrent or refractory intracranial
glioblastoma multiforme or gliosarcoma.

II. Determine the adverse event profile and tolerability of bevacizumab and temozolomide in
these patients.

SECONDARY OBJECTIVES:

I. Determine the efficacy of bevacizumab and temozolomide, in terms of 6-month
progression-free survival rate, in patients previously treated with temozolomide.

II. Determine the efficacy of bevacizumab and irinotecan hydrochloride, in terms of objective
response, in patients with measurable disease.

III. Determine the efficacy of bevacizumab and temozolomide, in terms of objective response,
in patients with measurable disease who were previously treated with temozolomide.

IV. Determine the toxicity profile and tolerability of bevacizumab and irinotecan
hydrochloride in these patients.

TERTIARY OBJECTIVES:

I. Assess the potential role of perfusion MRI and magnetic resonance spectroscopy imaging as
an early indicator of response to therapy after 2 weeks of treatment with bevacizumab.

II. Assess the potential role of perfusion MRI and magnetic resonance spectroscopy imaging as
a prognostic indicator based on images taken at baseline, at 2 weeks, and after 2 courses of
study treatment.

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to age (<
50 vs >= 50 years of age) and Karnofsky performance status (70-80% vs 90-100%). Patients are
randomized to 1 of 2 treatment arms with a 2:1 ratio (arm I:arm II).

ARM I: Patients receive bevacizumab IV over 30-90 minutes on days 1 and 15 and oral
temozolomide once daily on days 1-21.

ARM II: Patients receive bevacizumab IV as in Arm I followed by irinotecan hydrochloride IV
over 90 minutes on days 1 and 15.

In both arms, treatment repeats every 28 days for up to 24 courses in the absence of disease
progression or unacceptable toxicity. All patients undergo MRI at baseline and at every 2
courses (no 2-week MRI) per standard of care until progression or discontinuation of
treatment to assess areas of breakdown of the blood-brain barrier. Patients undergo an
additional MRI after study therapy. Consenting patients also undergo diffusion and perfusion
MRI and magnetic resonance spectroscopic imaging for correlative studies.

After completion of study therapy, patients are followed up for at least 1 month.

Inclusion Criteria:

- Histologically confirmed intracranial glioblastoma multiforme (GBM) or gliosarcoma

- Original histology of low-grade glioma with subsequent histological diagnosis of
GBM or gliosarcoma allowed

- Recurrent or refractory disease, meeting all of the following criteria:

- Must have received prior temozolomide

- Pathologic or imaging confirmation of tumor progression or regrowth required

- Confirmation of true progressive disease (rather than radiation necrosis) by
positron emission tomography, thallium scanning, MRI spectroscopy, or
surgical documentation required for patients who received prior interstitial
brachytherapy, Gliadel wafer, or stereotactic radiosurgery

- Unequivocal radiographic evidence of tumor progression by MRI within the past 14 days
(while on a stable dose of steroids for ? 5 days)

- No acute intratumoral hemorrhage on MRI

- Patients with MRI demonstrating old hemorrhage or subacute blood after a
neurosurgical procedure (biopsy or resection) are eligible

- Karnofsky performance status 70-100%

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception during and for at least 6 months
after completion of bevacizumab therapy

- Systolic blood pressure ? 160 mm Hg or diastolic blood pressure ? 90 mm Hg
(antihypertensive medication allowed)

- Able to undergo brain MRI scans with intravenous gadolinium

- Absolute neutrophil count ? 1,500 cells/mm?

- Platelet count ? 100,000 cells/mm?

- Hemoglobin ? 10 g/dL (transfusion or other intervention allowed)

- WBC ? 3,000 cells/mm?

- AST < 2 times upper limit of normal

- Bilirubin ? 1.6 mg/dL

- Creatinine < 1.5 mg/dL

- Urine protein:creatinine ratio ? 0.5 by urinalysis OR total urinary protein < 1,000 mg
by 24-hour urine collection

- INR < 1.4 (for patients not on warfarin)

- No patients with severely impaired renal function (i.e., estimated glomerular
filtration rate < 30 mL/min or on dialysis)

- No other prior invasive malignancy, except nonmelanomatous skin cancer or carcinoma in
situ of the cervix, unless the patient has been disease free and off therapy for that
disease for ? 3 years

- No severe, active comorbidity, defined as any of the following:

- Transmural myocardial infarction or unstable angina within the past 6 months

- Evidence of recent myocardial infarction or ischemia manifested as ST elevation
of ? 2 mm by EKG performed within the past 14 days

- New York Heart Association class II-IV congestive heart failure requiring
hospitalization within the past 12 months

- History of stroke or transient ischemic attack within the past 6 months

- Cerebrovascular accident within the past 6 months

- Serious and inadequately controlled cardiac arrhythmia

- Significant vascular disease (e.g., aortic aneurysm or history of aortic
dissection)

- Clinically significant peripheral vascular disease

- Evidence of bleeding diathesis or coagulopathy

- Serious or nonhealing wound, ulcer, or bone fracture

- Abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess
within the past 28 days

- Acute bacterial or fungal infection requiring intravenous antibiotics at the time
of study entry

- Chronic obstructive pulmonary disease exacerbation or other respiratory illness
requiring hospitalization or precluding study therapy within the past 14 days

- Acquired immune deficiency syndrome (AIDS)

- No significant traumatic injury within the past 28 days

- No known hypersensitivity to Chinese hamster ovary cell products or other recombinant
human antibodies

- No condition that impairs the ability to swallow pills (e.g., gastrointestinal tract
disease resulting in an inability to take oral medication; requirement for IV
alimentation; prior surgical procedures affecting absorption; or active peptic ulcer
disease)

- No disease that would obscure toxicity or dangerously alter drug metabolism

- No concurrent major surgical procedures

- Recovered from prior therapy

- Recent resection of recurrent or progressive tumor allowed provided the following
criteria are met:

- Failed prior radiotherapy that was completed ? 42 days ago

- Residual disease after resection of recurrent glioblastoma is not mandated

- More than 28 days since prior surgery or open biopsy

- More than 7 days since prior core or needle biopsy

- At least 28 days since prior investigational agents

- At least 14 days since prior vincristine

- At least 42 days since prior nitrosoureas

- At least 21 days since prior procarbazine

- At least 28 days since other prior cytotoxic therapy

- At least 7 days since prior noncytotoxic agents (e.g., interferon, tamoxifen,
thalidomide, or isotretinoin [except radiosensitizers])

- At least 14 days since prior enzyme-inducing antiepileptic drugs (EIAEDs)

- Concurrent non-hepatic EIAEDs allowed

- No other concurrent CYP3A4 inducers, such as rifampin or Hypericum perforatum (St.
John's wort)

- Concurrent full-dose anticoagulants (e.g., warfarin or low molecular weight heparin)
allowed provided all of the following criteria are met:

- No active bleeding or pathological condition that carries a high risk of bleeding
(e.g., tumor involving major vessels or known varices)

- In-range INR (usually between 2 and 3) on a stable dose of oral anticoagulants or
on a stable dose of low molecular weight heparin

- No concurrent highly active antiretroviral therapy

- No concurrent prophylactic use of growth factors
We found this trial at
93
sites
Concord, California 94520
?
mi
from
Concord, CA
Click here to add this to my saved trials
1500 E Duarte Rd
Duarte, California 91010
(626) 256-4673
City of Hope Comprehensive Cancer Center City of Hope is a leading research and treatment...
?
mi
from
Duarte, CA
Click here to add this to my saved trials
524 South Park Street
Kalamazoo, Michigan 49007
(269) 341-7654
Bronson Methodist Hospital Our healthcare system serves patients and families throughout southwest Michigan and northern...
?
mi
from
Kalamazoo, MI
Click here to add this to my saved trials
200 North Park Street
Kalamazoo, Michigan 49007
(269) 382-2500
West Michigan Cancer Center In 1994, Borgess Health Alliance and Bronson Healthcare Group opened the...
?
mi
from
Kalamazoo, MI
Click here to add this to my saved trials
4805 Northeast Glisan Street
Portland, Oregon 97213
(503) 215-1111
Providence Portland Medical Center We strive to give those we serve exceptional, compassionate health care...
?
mi
from
Portland, OR
Click here to add this to my saved trials
593 Eddy Street
Providence, Rhode Island 02903
401-444-4000
Rhode Island Hospital Founded in 1863, Rhode Island Hospital in Providence, RI, is a private,...
?
mi
from
Providence, RI
Click here to add this to my saved trials
60 Crittenden Blvd # 70
Rochester, New York 14642
(585) 275-2121
University of Rochester The University of Rochester is one of the country's top-tier research universities....
?
mi
from
Rochester, NY
Click here to add this to my saved trials
1 Akron General Ave
Akron, Ohio 44307
(330) 344-6000
Akron General Medical Center It
?
mi
from
Akron, OH
Click here to add this to my saved trials
Albuquerque, New Mexico 87109
?
mi
from
Albuquerque, NM
Click here to add this to my saved trials
170 North 1100 East
American Fork, Utah 84003
?
mi
from
American Fork, UT
Click here to add this to my saved trials
?
mi
from
Anderson, IN
Click here to add this to my saved trials
1500 East Medical Center Drive
Ann Arbor, Michigan 48109
800-865-1125
University of Michigan Comprehensive Cancer Center The U-M Comprehensive Cancer Center's mission is the conquest...
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
Annapolis, Maryland 21401
?
mi
from
Annapolis, MD
Click here to add this to my saved trials
Asheville, North Carolina 28801
?
mi
from
Asheville, NC
Click here to add this to my saved trials
Beech Grove, Indiana 46107
?
mi
from
Beech Grove, IN
Click here to add this to my saved trials
?
mi
from
Berkeley, CA
Click here to add this to my saved trials
?
mi
from
Billings, MT
Click here to add this to my saved trials
Boca Raton, Florida 33486
?
mi
from
Boca Raton, FL
Click here to add this to my saved trials
100 E Idaho St
Boise, Idaho 83712
(208) 381-2711
Saint Luke's Mountain States Tumor Institute For more than 100 years, St. Luke
?
mi
from
Boise, ID
Click here to add this to my saved trials
1501 Trousdale Drive
Burlingame, California 94010
?
mi
from
Burlingame, CA
Click here to add this to my saved trials
201 E Nicollet Blvd
Burnsville, Minnesota 55337
(952) 892-2000
Fairview Ridges Hospital Fairview Ridges Hospital is a 150-bed, Level III Trauma Care facility, offering...
?
mi
from
Burnsville, MN
Click here to add this to my saved trials
1303 North Main Street
Cedar City, Utah 84721
(435) 868-5680
Sandra L. Maxwell Cancer Center The Huntsman-Intermountain Cancer Center at Valley View Medical Center in...
?
mi
from
Cedar City, UT
Click here to add this to my saved trials
Charlotte, North Carolina 28204
?
mi
from
Charlotte, NC
Click here to add this to my saved trials
5841 S Maryland Ave
Chicago, Illinois 60637
1-773-702-6180
University of Chicago Comprehensive Cancer Center The University of Chicago Comprehensive Cancer Center (UCCCC) is...
?
mi
from
Chicago, IL
Click here to add this to my saved trials
4050 Coon Rapids Blvd NW
Coon Rapids, Minnesota 55433
(763) 236-6000
Mercy Hospital Mercy Hospital, located in Coon Rapids, Minnesota, is a 271-bed non-profit hospital that...
?
mi
from
Coon Rapids, MN
Click here to add this to my saved trials
1 Wyoming St,
Dayton, Ohio 45409
(937) 208-8000
Miami Valley Hospital Miami Valley Hospital (MVH) is passionate about providing the most recent medical...
?
mi
from
Dayton, OH
Click here to add this to my saved trials
?
mi
from
Dayton, OH
Click here to add this to my saved trials
Dayton, Ohio 45428
?
mi
from
Dayton, OH
Click here to add this to my saved trials
405 W Grand Ave
Dayton, Ohio 45405
(937) 723-3200
Grandview Hospital You'll feel like part of our family when you visit Grandview Medical Center...
?
mi
from
Dayton, OH
Click here to add this to my saved trials
2222 Philadelphia Dr
Dayton, Ohio 45406
(937) 734-2612
Good Samaritan Hospital - Dayton Good Samaritan Hospital (GSH) is passionate about providing the most...
?
mi
from
Dayton, OH
Click here to add this to my saved trials
9000 N. Main St.
Dayton, Ohio 45415
(937) 734-6784
Samaritan North Health Center Good Samaritan Hospital (GSH) is passionate about providing the most recent...
?
mi
from
Dayton, OH
Click here to add this to my saved trials
2799 W Grand Blvd
Detroit, Michigan 48202
(313) 916-2600
Henry Ford Hospital Founded in 1915 by auto pioneer Henry Ford and now one of...
?
mi
from
Detroit, MI
Click here to add this to my saved trials
6401 France Ave S
Edina, Minnesota 55435
(952) 924-5000
Fairview Southdale Hospital Fairview Health Services is an award-winning nonprofit health care system based in...
?
mi
from
Edina, MN
Click here to add this to my saved trials
Edison, New Jersey 08818
?
mi
from
Edison, NJ
Click here to add this to my saved trials
Fairbanks, Alaska 99701
?
mi
from
Fairbanks, AK
Click here to add this to my saved trials
Federal Way, Washington 98003
?
mi
from
Federal Way, WA
Click here to add this to my saved trials
1900 S Main St
Findlay, Ohio 45840
(419) 423-4500
Blanchard Valley Hospital For more than 100 years, Blanchard Valley Hospital has made quality care...
?
mi
from
Findlay, OH
Click here to add this to my saved trials
One Medical Center Drive
Franklin, Ohio 45005
(513) 424-2111
Atrium Medical Center - Middletown Regional Hospital Atrium Medical Center (Atrium) is built on the...
?
mi
from
Franklin, OH
Click here to add this to my saved trials
550 Osborne Rd NE
Fridley, Minnesota 55432
(763) 236-5000
Unity Hospital Unity Hospital is one of the Twin Cities
?
mi
from
Fridley, MN
Click here to add this to my saved trials
1600 Southwest Archer Road
Gainesville, Florida 32610
?
mi
from
Gainesville, FL
Click here to add this to my saved trials
Greenbrae, California 94904
?
mi
from
Greenbrae, CA
Click here to add this to my saved trials
24800 SE Stark St
Gresham, Oregon 97030
(503) 674-1122
Legacy Mount Hood Medical Center Legacy Mount Hood Medical Center, East County's full-service community hospital,...
?
mi
from
Gresham, OR
Click here to add this to my saved trials
Houston, Texas 77030
?
mi
from
Houston, TX
Click here to add this to my saved trials
Indianapolis, Indiana 46202
?
mi
from
Indianapolis, IN
Click here to add this to my saved trials
?
mi
from
Iowa City, IA
Click here to add this to my saved trials
1521 Gull Rd
Kalamazoo, Michigan 49048
269) 226-7000
Borgess Medical Center At Borgess, healing is our calling. This is the place where people...
?
mi
from
Kalamazoo, MI
Click here to add this to my saved trials
?
mi
from
Keene, NH
Click here to add this to my saved trials
3535 Southern Blvd
Kettering, Ohio 45429
(937) 298-4331
Kettering Medical Center Our flagship hospital, Kettering Medical Center, stands proudly in Kettering, Ohio. From...
?
mi
from
Kettering, OH
Click here to add this to my saved trials
Kirkland, Washington 98033
?
mi
from
Kirkland, WA
Click here to add this to my saved trials
1 Medical Center Dr
Lebanon, New Hampshire 03756
 (603) 650-5000
Dartmouth Hitchcock Medical Center Dartmouth-Hitchcock is a national leader in patient-centered health care and building...
?
mi
from
Lebanon, NH
Click here to add this to my saved trials
600 Highland Ave
Madison, Wisconsin 53792
(608) 263-6400
University of Wisconsin Hospital and Clinics UW Health strives to meet the health needs of...
?
mi
from
Madison, WI
Click here to add this to my saved trials
Maplewood, Minnesota 55109
?
mi
from
Maplewood, MN
Click here to add this to my saved trials
9200 W Wisconsin Ave
Milwaukee, Wisconsin 53226
(414) 805-3666
Froedtert and the Medical College of Wisconsin Froedtert Health combines with the Medical College of...
?
mi
from
Milwaukee, WI
Click here to add this to my saved trials
10150 SE 32nd Ave
Milwaukie, Oregon 97222
(503) 513-8300
Providence Milwaukie Hospital We strive to give those we serve exceptional, compassionate health care that...
?
mi
from
Milwaukie, OR
Click here to add this to my saved trials
800 E 28th St
Minneapolis, Minnesota 55407
(612) 863-4000
Abbott Northwestern Hospital Our hospital has a long and proud history as a health care...
?
mi
from
Minneapolis, MN
Click here to add this to my saved trials
Mobile, Alabama 36607
?
mi
from
Mobile, AL
Click here to add this to my saved trials
?
mi
from
Murray, UT
Click here to add this to my saved trials
5121 S Cottonwood St
Murray, Utah 84157
(801) 507-7000
Intermountain Medical Center Intermountain Medical Center is one of the most technologically advanced and patient-friendly...
?
mi
from
Murray, UT
Click here to add this to my saved trials
New Haven, Connecticut 6520
(203) 432-4771
Yale University Yale's roots can be traced back to the 1640s, when colonial clergymen led...
?
mi
from
New Haven, CT
Click here to add this to my saved trials
1275 York Ave
New York, New York 10021
(212) 639-2000
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
?
mi
from
New York, NY
Click here to add this to my saved trials
Novato, California 94945
?
mi
from
Novato, CA
Click here to add this to my saved trials
Ogden, Utah 84403
?
mi
from
Ogden, UT
Click here to add this to my saved trials
Philadelphia, Pennsylvania 19103
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
111 S 11th St
Philadelphia, Pennsylvania 19107
(215) 955-6000
Thomas Jefferson University Hospital Our hospitals in Center City Philadelphia share a 13-acre campus with...
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
Portland, Oregon 97216
?
mi
from
Portland, OR
Click here to add this to my saved trials
?
mi
from
Portland, OR
Click here to add this to my saved trials
1015 NW 22nd Ave
Portland, Oregon 97210
(503) 413-7711
Legacy Good Samaritan Hospital and Medical Center Located in the heart of Northwest Portland, Legacy...
?
mi
from
Portland, OR
Click here to add this to my saved trials
2801 N Gantenbein Ave
Portland, Oregon 97227
(503) 413-2200
Legacy Emanuel Hospital and Health Center Legacy Emanuel is nationally known for expertise in critical...
?
mi
from
Portland, OR
Click here to add this to my saved trials
?
mi
from
Provo, UT
Click here to add this to my saved trials
Richmond, Indiana 47374
?
mi
from
Richmond, IN
Click here to add this to my saved trials
3300 Oakdale Ave. N.
Robbinsdale, Minnesota 55422
763-520-5200
North Memorial Medical Health Center North Memorial Health Care is a comprehensive health care system...
?
mi
from
Robbinsdale, MN
Click here to add this to my saved trials
Rochester, New York 14620
?
mi
from
Rochester, NY
Click here to add this to my saved trials
3601 W 13 Mile Rd
Royal Oak, Michigan 48073
(248) 898-5000
William Beaumont Hospital-Royal Oak The largest Beaumont Hospital is located at 3601 W Thirteen Mile...
?
mi
from
Royal Oak, MI
Click here to add this to my saved trials
?
mi
from
Saint George, UT
Click here to add this to my saved trials
Saint Johnsbury, Vermont 05819
?
mi
from
Saint Johnsbury, VT
Click here to add this to my saved trials
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
?
mi
from
Saint Louis, MO
Click here to add this to my saved trials
3850 Park Nicollet Blvd
Saint Louis Park, Minnesota 55416
(952) 993-3123
Park Nicollet Clinic - Saint Louis Park Park Nicollet Health Services is a nonprofit, integrated...
?
mi
from
Saint Louis Park, MN
Click here to add this to my saved trials
333 Smith Ave
Saint Paul, Minnesota 55102
(651) 241-8000
United Hospital United Hospital is the largest hospital in the Twin Cities east metro area,...
?
mi
from
Saint Paul, MN
Click here to add this to my saved trials
Salt Lake City, Utah 84106
?
mi
from
Salt Lake City, UT
Click here to add this to my saved trials
Salt Lake City, Utah 84106
?
mi
from
Salt Lake City, UT
Click here to add this to my saved trials
8th Ave & C St
Salt Lake City, Utah 84143
(801) 408-1100
LDS Hospital LDS Hospital provides clinical excellence to our community in a wide range of...
?
mi
from
Salt Lake City, UT
Click here to add this to my saved trials
San Francisco, California 94114
?
mi
from
San Francisco, CA
Click here to add this to my saved trials
Scottsdale, Arizona 85260
?
mi
from
Scottsdale, AZ
Click here to add this to my saved trials
Seattle, Washington 98101
(888) 862-2737
Virginia Mason Medical Center Established in 1920, Virginia Mason began as an 80-bed hospital with...
?
mi
from
Seattle, WA
Click here to add this to my saved trials
1959 NE Pacific St
Seattle, Washington 98195
(206) 598-3300
University of Washington Medical Center University of Washington Medical Center is one of the nation's...
?
mi
from
Seattle, WA
Click here to add this to my saved trials
3130 N. County Rd. 25-A
Troy, Ohio 45373
(937) 440-4000
Upper Valley Medical Center Upper Valley Medical Center (UVMC) is a not-for-profit health care provider...
?
mi
from
Troy, OH
Click here to add this to my saved trials
19300 SW 65th Ave
Tualatin, Oregon 97062
(503) 692-1212
Legacy Meridian Park Hospital Legacy Meridian Park Medical Center opened its new Chest Pain Center,...
?
mi
from
Tualatin, OR
Click here to add this to my saved trials
Vallejo, California 94589
?
mi
from
Vallejo, CA
Click here to add this to my saved trials
400 NE Mother Joseph Pl
Vancouver, Washington 98664
(360) 256-2000
PeaceHealth Southwest Medical Center n 1858, a pioneering nun, Mother Joseph, opened a hospital that...
?
mi
from
Vancouver, WA
Click here to add this to my saved trials
500 S Maple Street
Waconia, Minnesota 55387
952-442-2191
Ridgeview Medical Center Ridgeview Medical Center is an independent, nonprofit, regional health care system located...
?
mi
from
Waconia, MN
Click here to add this to my saved trials
Walnut Creek, California 94598
?
mi
from
Walnut Creek, CA
Click here to add this to my saved trials
?
mi
from
Woodbury, MN
Click here to add this to my saved trials
1141 N Monroe Dr
Xenia, Ohio 45385
(937) 352-2000
Greene Memorial Hospital For 65 years, Greene Memorial Hospital in Xenia, Ohio, has met the...
?
mi
from
Xenia, OH
Click here to add this to my saved trials