PRET: Patients Prone to Recurrence After Endovascular Treatment
Status: | Completed |
---|---|
Conditions: | Cardiology, Neurology |
Therapuetic Areas: | Cardiology / Vascular Diseases, Neurology |
Healthy: | No |
Age Range: | 18 - Any |
Updated: | 3/28/2019 |
Start Date: | June 2007 |
End Date: | December 2015 |
PRET: Patients Prone to Recurrence After Endovascular Treatment. A Randomized Trial Comparing Platinum and Hydrogel-coated Coils
The PRET study aims at comparing two types of coils used in the endovascular treatment of
intracranial aneurysms. The first type made of platinum has been used for more than 15 years.
The other, referred to as hydrocoil, containing in addition to platinum a polymer layer that
expands when in contact with blood, has been in use since 2002. The hypothesis of the PRET
study is that the newer hydrocoil will be more effective and yet as safe as the older
platinum coil.
intracranial aneurysms. The first type made of platinum has been used for more than 15 years.
The other, referred to as hydrocoil, containing in addition to platinum a polymer layer that
expands when in contact with blood, has been in use since 2002. The hypothesis of the PRET
study is that the newer hydrocoil will be more effective and yet as safe as the older
platinum coil.
Inclusion Criteria:
- All patients presenting at least one aneurysm 'prone to recurrence after endovascular
treatment' (PRET), defined for the sake of this study as:
- PRET-1: One ruptured or unruptured aneurysm, never treated, with a dimension
≥10mm (longest axis, including thrombosed portions of large or giant aneurysms);
for ruptured lesions, patients should be in WFNS grade I, II or III.
- PRET-2: an Aneurysm presenting a major recurrence after previous coiling; and
judged by the neurovascular team to require elective treatment.
- The anatomy of the lesion is such that endovascular treatment is possible with both
types of coils (not necessarily certain or probable)
- The endovascular physician is content to use either type of coils (platinum or
hydrogel-coated coils) but no other type of coils
- Patient is 18 or older
- Life expectancy is more than 2 years
Exclusion Criteria:
- Presence of other aneurysms requiring treatment during the same session
- Patients with associated cerebral arteriovenous malformations
- When parent vessel occlusion, without simultaneous endosaccular coiling of the
aneurysm, is the primary intent of the procedure
- Any absolute contraindication to endovascular treatment, angiography, or anaesthesia
such as severe allergies to contrast or medications
We found this trial at
19
sites
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University of Cincinnati Medical Center Opening in 1823 as the country
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Cleveland Clinic Cleveland Clinic is committed to principles as presented in the United Nations Global...
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3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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Saint Francis Medical Center Saint Francis Medical Center is a 282-bed facility serving more than...
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171 Ashley Avenue
Charleston, South Carolina 29425
Charleston, South Carolina 29425
843-792-1414
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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University of Virginia Health System UVA Health System includes a 604-bed hospital, level I trauma...
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Borgess Medical Center At Borgess, healing is our calling. This is the place where people...
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600 Highland Ave
Madison, Wisconsin 53792
Madison, Wisconsin 53792
(608) 263-6400
University of Wisconsin Hospital and Clinics UW Health strives to meet the health needs of...
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940 NE 13th St
Oklahoma City, Oklahoma 73190
Oklahoma City, Oklahoma 73190
(405) 271-6458
University of Oklahoma Health Sciences Center The OU Health Sciences Center is composed of seven...
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Mayo Clinic Rochester Mayo Clinic is a nonprofit worldwide leader in medical care, research and...
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