Post-Traumatic Stress Disorder (PTSD) Symptom Study



Status:Completed
Conditions:Psychiatric
Therapuetic Areas:Psychiatry / Psychology
Healthy:No
Age Range:18 - Any
Updated:9/21/2018
Start Date:April 1, 2000
End Date:April 1, 2005

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Longitudinal Evaluation of Chronic Combat-Related PTSD

The primary goals for this investigation are to quantify: (1) fluctuations in PTSD symptom
reports when assessed at bi-weekly intervals; (2) change in PTSD symptoms associated with
stressful life events; and (3) change in PTSD symptoms associated with perceived social
support.

The primary goals for this investigation are to quantify: (1) fluctuations in PTSD symptom
reports when assessed at bi-weekly intervals; (2) change in PTSD symptoms associated with
stressful life events; and (3) change in PTSD symptoms associated with perceived social
support.

Despite increased sophistication in measurement of PTSD, little is known about the long-term
longitudinal course of this disorder or the fluctuation of symptoms over time. Because
previous studies have focused on the development and persistence of symptoms immediately
following a stressor, the course of the chronic disorder has been largely unexplored.
Although there is evidence of both persistence and fluctuation of PTSD symptom presentation
in Vietnam veterans, little is known about how much and in what ways symptoms change over
time. This investigation will increase understanding of the nature and extent of symptom
fluctuation as well as the longitudinal course of PTSD as first steps in determining which
variables affect that course and how clinicians might intervene to alter it.

Aversive life events may constitute one factor that influences the course of chronic PTSD.
Researchers and clinicians have frequently hypothesized that stressful life events account
for much of the variability in course of chronic PTSD; individuals with PTSD may have a
compromised ability to cope with stressors, and such events may worsen existing symptoms.
Social support is another variable thought to affect the course of post-trauma
symptomatology. Support from other persons has been shown to both promote psychological
health in general and to protect against psychological deterioration in times of stress. This
investigation will examine aversive life events and perceived social support to determine
their relationships over time to symptoms of PTSD.

Inclusion Criteria:

1. Vietnam vets who served in combat

2. Diagnosis of current or lifetime PTSD

Excluded if severe psychosis, current diagnosis of acute substance dependence, if no stable
residence in past 6 months

Exclusion Criteria:

Actively psychosis, currently suicidal or homicidal, without telephone access, or had
experienced substance or alcohol abuse or dependence within the previous six months.
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