Efficacy of Secukinumab Compared to Adalimumab in Patients With Psoriatic Arthritis



Status:Active, not recruiting
Conditions:Arthritis, Psoriasis
Therapuetic Areas:Dermatology / Plastic Surgery, Rheumatology
Healthy:No
Age Range:18 - Any
Updated:2/24/2019
Start Date:April 3, 2017
End Date:December 26, 2019

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A Randomized, Double-blind, Active Control, Multicenter Study to Evaluate the Efficacy at Week 52 of Secukinumab Monotherapy Compared With Adalimumab Monotherapy in Patients With Active Psoriatic Arthritis

The purpose of this study is to compare the safety and efficacy of secukinumab monotherapy
and adalimumab monotherapy in patients with active psoriatic arthritis who are naïve to
biologic therapy and are intolerant or having inadequate response to conventional DMARDs


Inclusion Criteria:

- Diagnosis of PsA classified by CASPAR; Rheumatoid factor and anti-CCP antibodies
negative; diagnosis of active plaque psoriasis, with at least one psoriatic plaque of
≥2cm diameter or nail changes consistent with psoriasis or documented history of
plaque psoriasis; inadequate control of symptoms with NSAIDs; inadequate control of
symptoms with a conventional DMARD.

Exclusion Criteria:

- Pregnant or nursing women, evidence of ongoing infectious or malignant process;
previous exposure to any biologic drug for Psoriatic Arthritis or Psoriasis; subjects
taking high potency opioid analgesics; ongoing use of prohibited psoriasis treatments
/ medications; previous treatment with any cell-depleting therapies including but not
limited to anti-CD20, investigational agents.

Other protocol-defined inclusion/exclusion criteria may apply
We found this trial at
27
sites
Kennewick, Washington 99336
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Arlington, Texas 76012
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Arlington, TX
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Austin, Texas 78759
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Bethlehem, Pennsylvania 18015
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Boulder, Colorado 80304
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Bowling Green, Kentucky 42101
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Bowling Green, KY
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Burlington, Vermont 05401
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Coeur d'Alene, Idaho 83814
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Dallas, Texas 75216
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Danbury, Connecticut 06810
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Danbury, CT
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Duncansville, Pennsylvania 16635
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Duncansville, PA
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Durham, North Carolina 27710
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Durham, NC
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Fountain Valley, California 92708
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Fountain Valley, CA
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Fullerton, California 92835
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Fullerton, CA
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Glendale, Wisconsin 53217
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Kogarah, New South Wales 2217
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Kogarah,
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La Mesa, California 91942
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Lincoln, Nebraska 68506
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Lincoln, NE
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Mesquite, Texas 75150
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New Bern, North Carolina 28562
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Omaha, Nebraska 68144
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Omaha, NE
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Rochester, New York 14615
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Rochester, NY
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Saint Louis, Missouri 63128
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Saint Louis, MO
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Seattle, Washington 98103
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Seattle, WA
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Spokane, Washington 99202
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Spokane, WA
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Tamarac, Florida 33321
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Tamarac, FL
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Upland, California 91786
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Upland, CA
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