Efficacy of Secukinumab Compared to Adalimumab in Patients With Psoriatic Arthritis
Status: | Active, not recruiting |
---|---|
Conditions: | Arthritis, Psoriasis |
Therapuetic Areas: | Dermatology / Plastic Surgery, Rheumatology |
Healthy: | No |
Age Range: | 18 - Any |
Updated: | 2/24/2019 |
Start Date: | April 3, 2017 |
End Date: | December 26, 2019 |
A Randomized, Double-blind, Active Control, Multicenter Study to Evaluate the Efficacy at Week 52 of Secukinumab Monotherapy Compared With Adalimumab Monotherapy in Patients With Active Psoriatic Arthritis
The purpose of this study is to compare the safety and efficacy of secukinumab monotherapy
and adalimumab monotherapy in patients with active psoriatic arthritis who are naïve to
biologic therapy and are intolerant or having inadequate response to conventional DMARDs
and adalimumab monotherapy in patients with active psoriatic arthritis who are naïve to
biologic therapy and are intolerant or having inadequate response to conventional DMARDs
Inclusion Criteria:
- Diagnosis of PsA classified by CASPAR; Rheumatoid factor and anti-CCP antibodies
negative; diagnosis of active plaque psoriasis, with at least one psoriatic plaque of
≥2cm diameter or nail changes consistent with psoriasis or documented history of
plaque psoriasis; inadequate control of symptoms with NSAIDs; inadequate control of
symptoms with a conventional DMARD.
Exclusion Criteria:
- Pregnant or nursing women, evidence of ongoing infectious or malignant process;
previous exposure to any biologic drug for Psoriatic Arthritis or Psoriasis; subjects
taking high potency opioid analgesics; ongoing use of prohibited psoriasis treatments
/ medications; previous treatment with any cell-depleting therapies including but not
limited to anti-CD20, investigational agents.
Other protocol-defined inclusion/exclusion criteria may apply
We found this trial at
27
sites
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