Effect of Oxymetazoline Hydrochloride in Combination With Fluticasone Propionate on the Apnea Hypopnea Index (AHI) in Subject With Persistent Nasal Congestion and Mild Obstructive Sleep Apnea

To evaluate the effectiveness of the addition of intranasal oxymetazoline to ongoing optimal
doses of intranasal fluticasone propionate on the apnea/hypopnea index (AHI) in subjects with
persistent nasal congestion and mild obstructive sleep apnea secondary to perennial allergic
or non-allergic rhinitis despite treatment with the recommended doses of NGCS. The NOX T3
portable sleep monitor will be used to measure the AHI.

1. The Flow Sensor, as part of the NOX T3 portable monitor, will be used to assess flow
limitation of the upper airway through calculation of the flattening index, a marker of
upper airway resistance.

2. The Congestion Quantifier 7 (CQ7) questionnaire will be used to assess for an
improvement in nasal congestion based on symptoms from the prior week.

3. The Nasal Congestion Visual Analog Scale (VAS) will be used to identify the changes in
the severity of nasal congestion on a day to day basis.

4. The Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) will be used to assess the
impact of perennial rhinitis and nasal congestion on activities of daily living.

Inclusion Criteria:

1. Male and female subjects 18 - 65 years of age.

2. At least a one year history of perennial allergic or non-allergic rhinitis.

3. Subjects must be on the maximum recommended doses of one of the following NGCS for at
least one month. (See Table I)

4. AHI per hour of sleep > 5 and <15, minimum SpO2 88, indicating mild obstructive sleep
apnea).

5. Average Nasal Congestion VAS of > 3-10 indicating moderate to severe nasal congestion
between visits 1 and 2 based on daily symptoms (average of 7 scores).

6. Average Congestion Quantifier 7 score of 7 between visits 1 and 2 based on weekly
symptoms (average of 2 scores).

7. Willingness to participate as indicated by signed informed consent.

Exclusion Criteria:

1. Presence of hypersensitivity to oxymetazoline or fluticasone propionate.

2. Subjects receiving allergen immunotherapy but not on a stable maintenance regimen for
at least 30 days before the first study visit.

3. If the subject has perennial allergic rhinitis, he/she should not be entered into this
study eight weeks before, during, or six weeks after any seasonal exacerbation.

4. Women who are pregnant or lactating.

5. Other known nasal diseases likely to affect deposition of oxymetazoline such as
sinusitis, nasal polyps, or major nasal structural malformations.

6. Respiratory tract infections in the last 14 days.

7. Infections requiring antibiotics in the last 14 days.

8. Asthma or chronic obstructive pulmonary disease (COPD) requiring roflumilast or more
than the recommended doses of inhaled corticosteroids, beta agonists, or
antimuscarinic agents.

9. No systemic glucocorticosteroids for one month prior or during the study.

10. Cardiovascular disease with uncontrolled hypertension (BP160/80), arrhythmias and/or
congestive heart failure.

11. Insulin-dependent diabetes mellitus and/or diabetic retinopathy.

12. Subjects with mild OSA (AHI 5-14) and SpO2 <88 for > 5 min during sleep that is
identified during the screening portable sleep study.

13. Hypertension requiring more than two drugs, with the exception of hydrochlorothiazide,
to achieve control.

14. A history of drug or alcohol abuse within the past 5 years.

15. Subjects who are currently abusing alcohol, illicit drugs, benzodiazepines, or
narcotics.

16. Inability to cooperate, comply with study procedures or communicate with the
investigator to successfully complete the study.

17. A history of benign prostate hypertrophy necessitating treatment.

18. A history of psychiatric problems which, in the opinion of the investigators, would
impair participation in the study.

19. Subjects with a planned hospitalization during the study.

20. An infirmity, disability, or geographical location which seems likely to prevent
regular attendance for subject visits.

21. Subjects with obstructive sleep apnea syndrome requiring CPAP therapy.

22. Subjects diagnosed with central sleep apnea (> 5 central events per hour) or moderate
to severe OSA (AHI > 15) and SpO2 <88 for > 5 min during sleep identified during
screening.

23. Use of the following medications within the time period specified below prior to Day
-7 (Table 2).