Effect of iNO on Invasively Derived Pulmonary Pressures in Patients With PAH
| Status: | Completed |
|---|---|
| Conditions: | High Blood Pressure (Hypertension) |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 9/26/2018 |
| Start Date: | April 2016 |
| End Date: | December 2016 |
Effects of iNO on Invasively Derived Pulmonary Vascular Parameters in Patients With Pulmonary Arterial Hypertension
Pulmonary hypertension is characterized by an increase in the pressures in the blood supply
to the lungs greater than a mean pressure of 25mmHg and a concomitant increase in overall
pulmonary vascular resistance (PVR). In patients who have remodeling of their pulmonary
vasculature, PVR will increase with exercise instead of decreasing as it would in normal
patients. Based on published evidence, the investigators intend to investigate the effects of
inhaled nitric oxide (iNO) on patients undergoing standard exercise techniques who have
separately and previously had an implanted pulmonary artery monitoring device (CardioMems by
St Jude Medical, Inc.) placed.
to the lungs greater than a mean pressure of 25mmHg and a concomitant increase in overall
pulmonary vascular resistance (PVR). In patients who have remodeling of their pulmonary
vasculature, PVR will increase with exercise instead of decreasing as it would in normal
patients. Based on published evidence, the investigators intend to investigate the effects of
inhaled nitric oxide (iNO) on patients undergoing standard exercise techniques who have
separately and previously had an implanted pulmonary artery monitoring device (CardioMems by
St Jude Medical, Inc.) placed.
Inclusion Criteria:
- Males or females age 18 to 80 years with a diagnosis of pulmonary arterial
hypertension (WHO Group I pulmonary hypertension).
- Must be able to read and understand English and consent for themselves
- Previously implanted CardioMems continuous PA pressure
- Ambulatory and able to complete 6MWD test.
Exclusion Criteria:
- Pregnant or lactating females; negative pregnancy test as confirmed by evaluation of
data from pre-enrolled Risk Evaluation and Mitigation Strategies (REMS) program.
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