Comparing Effectiveness of Duloxetine and Desipramine in Patients With Chronic Pain: A Pragmatic Trial Using Point of Care Randomization
| Status: | Recruiting |
|---|---|
| Conditions: | Chronic Pain, Chronic Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 9/26/2018 |
| Start Date: | September 20, 2018 |
| End Date: | July 31, 2020 |
| Contact: | Vafi Salmasi, MD. |
| Email: | vsalmasi@stanford.edu |
| Phone: | 650-725-0246 |
Over 100 million Americans suffer from chronic pain resulting in annual cost of roughly $635
billion. Limited treatments are available for this widespread disease. The data supporting
these treatments lack generalizability to patients with more serious medical and
psychological comorbidities who are often excluded from explanatory efficacy trials. Our work
aims to integrate randomized comparative effectiveness research with patient care. The
investigators will randomize the patients and collect data using an open-source learning
healthcare system already in use in our department to monitor patients' progress:
Collaborative Health Outcomes Information Registry (CHOIR). Collaborative Health Outcomes
Information Registry uses the National Institute of Health Patient Reported Outcomes
Measurement Information System item banks for comparative metrics through computer adaptive
testing. The investigators will leverage the advantage of this novel system to compare
effectiveness of duloxetine and desipramine in decreasing pain in patients with chronic pain.
The investigators will also compare adherence of patients to these two commonly used
medications over a period of six months. This will evaluate feasibility of integrating
randomized comparative effectiveness research with patient care in subspecialty clinics.
Collaborative Health Outcomes Information Registry can then be applied for numerous future
trials to advance our knowledge in perioperative and pain medicine.
billion. Limited treatments are available for this widespread disease. The data supporting
these treatments lack generalizability to patients with more serious medical and
psychological comorbidities who are often excluded from explanatory efficacy trials. Our work
aims to integrate randomized comparative effectiveness research with patient care. The
investigators will randomize the patients and collect data using an open-source learning
healthcare system already in use in our department to monitor patients' progress:
Collaborative Health Outcomes Information Registry (CHOIR). Collaborative Health Outcomes
Information Registry uses the National Institute of Health Patient Reported Outcomes
Measurement Information System item banks for comparative metrics through computer adaptive
testing. The investigators will leverage the advantage of this novel system to compare
effectiveness of duloxetine and desipramine in decreasing pain in patients with chronic pain.
The investigators will also compare adherence of patients to these two commonly used
medications over a period of six months. This will evaluate feasibility of integrating
randomized comparative effectiveness research with patient care in subspecialty clinics.
Collaborative Health Outcomes Information Registry can then be applied for numerous future
trials to advance our knowledge in perioperative and pain medicine.
Inclusion criteria:
1. Age of 18 years old or above
2. Persistent pain for more than 3 months
3. Candidate for treatment by anti-depressant based on treating pain provider
Exclusion criteria:
1. Prior failure of duloxetine and/or desipramine (patients who have failed other TCAs or
SNRIs can be considered for the trial based on the reason for previous medication
failure)
2. Contraindication to taking duloxetine or desipramine
3. Patient refusal
We found this trial at
1
site
Click here to add this to my saved trials
