A Study of Lasmiditan (LY573144) Over Four Migraine Attacks

Inclusion Criteria:

- Migraine with or without aura fulfilling the International Headache Society (IHS)
diagnostic criteria 1.1 and 1.2.1

- History of disabling migraine for at least 1 year

- Migraine onset before the age of 50 years

- History of 3 to 8 migraine attacks per month (<15 headache days per month) during the
past 3 months

- MIDAS score ≥11

- Able and willing to complete an eDiary to record the details of each migraine attack
treated with study drug

- Women of child-bearing potential must be using or willing to use a highly effective
form of contraception

- Agree not to post any personal medical data or information related to the study on any
website or social media site until the entire trial has completed

Exclusion Criteria:

- Known hypersensitivity to lasmiditan, or to any excipient of lasmiditan oral tablets

- History or evidence of hemorrhagic stroke, epilepsy, or any other condition placing
the participant at increased risk of seizures

- History of recurrent dizziness and/or vertigo including benign paroxysmal positional
vertigo, Meniere's disease, vestibular migraine, and other vestibular disorders

- History of diabetes mellitus with complications (diabetic retinopathy, nephropathy, or
neuropathy)

- History of orthostatic hypotension with syncope

- Significant renal or hepatic impairment in the opinion of the investigator or if they
meet hepatic monitoring criteria

- Participants who, in the investigator's judgment, are actively suicidal and therefore
deemed to be at significant risk for suicide

- History, within past 12 months, of chronic migraine or other forms of primary or
secondary chronic headache disorder (eg, hemicranias continua, medication overuse
headache where headache frequency is ≥15 headache days per month)

- Use of more than 3 doses per month of either opioids or barbiturates

- Initiation of or a change in concomitant medication to reduce the frequency of
migraine episodes within 3 months prior to screening

- Pregnant or breast-feeding women

- History of drug or alcohol abuse/dependence within 1 year prior to screening

- Any medical condition or clinical laboratory test which in the judgment of the
investigator makes the participant unsuitable for the study

- Currently enrolled in any other clinical study involving an investigational product

- Relatives of, or staff directly reporting to, the Investigator

- Participants who are employees of the sponsor