Obesity Risk in African American Women is Determined by a Diet-by-phenotype Interaction
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 19 - 45 |
| Updated: | 3/29/2019 |
| Start Date: | March 19, 2019 |
| End Date: | August 1, 2023 |
| Contact: | Laura Lee Goree, MS, RD, LD |
| Email: | LLG@uab.edu |
| Phone: | 205-934-4386 |
The Scientific Premise of this study is that the high level of obesity displayed by African
American (AA) women is due to the ability to secrete large amounts of insulin when sugary
foods are consumed. When AA women eat a diet rich in starchy or sugary food (a
"high-glycemic" diet that stimulates insulin secretion), the food that is eaten is stored as
fat rather than being burned as fuel. The investigators previous research has suggested that
AA women have an easier time losing weight and keeping it off when eating a low-glycemic
diet. The proposed study will be the first randomized clinical trial to test the effect of
high and low glycemic diets for weight loss and weight-loss-maintenance in obese AA women.
American (AA) women is due to the ability to secrete large amounts of insulin when sugary
foods are consumed. When AA women eat a diet rich in starchy or sugary food (a
"high-glycemic" diet that stimulates insulin secretion), the food that is eaten is stored as
fat rather than being burned as fuel. The investigators previous research has suggested that
AA women have an easier time losing weight and keeping it off when eating a low-glycemic
diet. The proposed study will be the first randomized clinical trial to test the effect of
high and low glycemic diets for weight loss and weight-loss-maintenance in obese AA women.
Inclusion Criteria:
- BMI 30-45 kg/m2
- Sedentary to moderately active (<2 hours/wk of moderate, structured, intentional
exercise.
- Normal menstrual cycle
Exclusion Criteria:
- History of eating disorder
- daily use of tobacco (>1 pack/wk)
- change in weight greater than 5 pounds in previous 3 months
- presence of any condition (e.g. PCOS) or use of any medication (e.g. glucocorticoid)
deemed by the project physician to interfere with study outcomes
- applicants will be screened with a standard oral glucose tolerance test. If a
participant's 2 hour glucose if >200, they will not be able to enroll in the study.
We found this trial at
1
site
1720 2nd Ave S
Birmingham, Alabama 35233
Birmingham, Alabama 35233
(205) 934-4011
Principal Investigator: Barbara Gower, PhD
Phone: 205-934-4386
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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