Prospectively Collected Pleural Biopsies for Validation of Malignant Pleural Mesothelioma Prognostic Biomarkers

The purpose of this research study is to test a new method for determining the stage and
prognosis of patients with malignant pleural mesothelioma. Currently, it is not possible to
accurately determine cancer stage prior to surgery or another treatment. This new method may
allow doctors to better classify cancer stage and give a better estimate for prognosis prior
to surgery or another treatment.

In this research study, the investigators would like to use biopsied tissue to study certain
characteristics that will help test the new method for determining cancer stage and
estimating prognosis.

In this research study, the investigators are...

- Obtaining pleural specimens at the time of routine diagnostic biopsy during the
participant's standard treatment.

- Storing your biopsied tissue

- Studying the tissue to determine if the new method of staging and prognosis is accurate
and valid

Inclusion Criteria:

- All adult patients with a diagnosis of malignant pleural mesothelioma undergoing

- diagnostic pleural biopsy

- pleuroscopy

- and/or VATS resections

- Participants must be 18 years of age or older.

Exclusion Criteria:

-Any patient who is found to be unsuitable for

- surgery,

- treatment

- diagnosis,