Analysis of Headache Chronification With Imaging, Deep Phenotyping, and Proteomics

The purpose of our study is to better understand disease processes and risk factors involved
in onset of chronic daily headaches/Chronic Migraines. Further, The Investigators hopes to
learn more about the etiology and disease mechanisms to optimize treatment strategies and
determine prophylactic measures.

Participation in this research study, will include online questionnaires, a blood sample, a
lumbar puncture, and a magnetic resonance imaging (MRI) scan without contrast to measure
brain activity. Participant may select to participate in a magnetic resonance imaging (MRI)
scan and/ or lumbar puncture. participating in atleast 3 procedures is required (blood draw,
online questionnaires , MRI and/or Spinal Tap.

The study recruits participants with headache ( any type of headaches), and patients with no
headaches ( or less than 2/year). Participants do not need to have a specified headache type.
All participants are asked to complete an on-line survey to characterize a number of
phenotypic features felt to be relevant by the Investigators. Three independent study groups
(imaging, proteomics/genetics, and phenotyping) analyze data independently and stratify the
data. Then, by group analysis, correlation among the different modalities is sought to
identify features that distinguish common elements that might help elucidate features that
could predict which patients with episodic headache are likely to progress to chronic, and
which patients without headache might be at greater risk to develop new daily persistent
headache.

Inclusion Criteria:

- Subjects must agree to sign informed consent.

- Subject must be able to or at least with some help willing to complete online
questionnaires in English .

- Willing to comply with study instructions.

Exclusion Criteria:

* Understand English.