DECT in Imaging Patients With Solid Organ Cancer With Intracranial Metastasis
| Status: | Recruiting |
|---|---|
| Conditions: | Brain Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 9/29/2018 |
| Start Date: | August 24, 2018 |
| End Date: | May 31, 2020 |
| Contact: | Jason Johnson |
| Email: | jjohnson12@mdanderson.org |
| Phone: | 713-792-8443 |
Advanced CT Imaging Optimization for the Detection of Intracranial Metastasis
This trial studies how well dual energy computed tomography (DECT) works in imaging patients
with solid organ cancer that has spread to the brain. Imaging techniques, such as DECT, may
help find and diagnose tumor cells and find out how far the tumor cells have spread in the
brain.
with solid organ cancer that has spread to the brain. Imaging techniques, such as DECT, may
help find and diagnose tumor cells and find out how far the tumor cells have spread in the
brain.
PRIMARY OBJECTIVES:
I. To optimize two major parameters of computed tomography (CT) imaging for optimal detection
of intracranial metastatic lesions; virtual monochromatic image reconstruction and contrast
bolus timing.
II. To measure the detection accuracy of CT compared to the diagnostic standard of care
gadolinium-based "Gamma Knife (GK)" protocol magnetic resonance imaging (MRI).
OUTLINE:
Within 7 days before the standard Gamma Knife MRI, patients undergo DECT scan over 6 seconds
at 1.5, 5, 10, and 20 minutes after receiving the contrast agent.
I. To optimize two major parameters of computed tomography (CT) imaging for optimal detection
of intracranial metastatic lesions; virtual monochromatic image reconstruction and contrast
bolus timing.
II. To measure the detection accuracy of CT compared to the diagnostic standard of care
gadolinium-based "Gamma Knife (GK)" protocol magnetic resonance imaging (MRI).
OUTLINE:
Within 7 days before the standard Gamma Knife MRI, patients undergo DECT scan over 6 seconds
at 1.5, 5, 10, and 20 minutes after receiving the contrast agent.
Inclusion Criteria:
- Adult patient with pathology-proven solid organ cancer
- MRI of the brain with contrast, positive for greater than four metastatic lesions
- One lesion with a single greatest diameter on contrast-enhanced MRI of 1 cm or
greater
- Planned treatment with stereotactic radiosurgery
Exclusion Criteria:
- Known allergy to iodine-based contrast agents
- Renal failure as defined by a glomerular filtration rate (GFR) less than 30 or use of
hemodialysis
- Prior nephrectomy or planned nephrectomy
- Prior central nervous system malignancy
- Prior brain radiation
- Pregnant women are excluded
We found this trial at
1
site
Houston, Texas 77030
Principal Investigator: Jason M. Johnson
Phone: 713-792-8443
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