Reversing Diabetic Peripheral Neuropathy Through Exercise
| Status: | Recruiting |
|---|---|
| Conditions: | Diabetic Neuropathy, Neurology |
| Therapuetic Areas: | Endocrinology, Neurology |
| Healthy: | No |
| Age Range: | 40 - 70 |
| Updated: | 1/16/2019 |
| Start Date: | November 28, 2018 |
| End Date: | December 2022 |
| Contact: | Danielle Costanzo |
| Email: | danielle.costanzo@nyumc.org |
| Phone: | 212 263 0380 |
This cross-over design study proposes an innovative multinuclear MRI approach to gain
mechanistic insight into the exercise-associated adaptations in lower leg muscle function and
peripheral nerve integrity of patients with diabetic peripheral neuropathy (DPN). Currently,
there are no therapies to prevent or reverse the progress of DPN. This study will use novel
multinuclear MRI technology to understand how exercise affects skeletal muscle and peripheral
nerve integrity and function in patients with DPN. This study will prescribe a 4-week
non-exercise phase followed by a 10-week exercise program (with both aerobic and
strengthening components) to 40 DPN patients who will receive personal supervision from
health professionals.
mechanistic insight into the exercise-associated adaptations in lower leg muscle function and
peripheral nerve integrity of patients with diabetic peripheral neuropathy (DPN). Currently,
there are no therapies to prevent or reverse the progress of DPN. This study will use novel
multinuclear MRI technology to understand how exercise affects skeletal muscle and peripheral
nerve integrity and function in patients with DPN. This study will prescribe a 4-week
non-exercise phase followed by a 10-week exercise program (with both aerobic and
strengthening components) to 40 DPN patients who will receive personal supervision from
health professionals.
Inclusion Criteria:
- Be between the ages of 40 and 70
- Clinical diagnosis of Type 2 diabetes
- Clinical diagnosis of DPN
- Have a BMI less than 40 kg/m2 (due to magnet bore restrictions)
- Able to walk unassisted
Exclusion Criteria:
- Serious cardiac pathology or musculoskeletal problems that would limit exercise
ability
- MNSI score < 1
- Current open wound or history of plantar ulcer for the last 3 months
- Partial foot amputations
- Inability to ambulate without assistive device
- Stroke or other central nervous system pathology
- Stage 2 hypertension (resting blood pressure >160 systolic or >100 diastolic)
- Contraindications to 3T whole body MRI scanners (e.g., pacemaker, cerebral aneurysm
clip, cochlear implant, presence of shrapnel in strategic locations, metal in the eye,
claustrophobia, or other problems).
- Subjects with alcoholism, chronic drug use, chronic gastrointestinal disease, or renal
or hepatic impairment
- Pregnant women and children
We found this trial at
1
site
550 1st Ave
New York, New York 10016
New York, New York 10016
(212) 263-7300
Principal Investigator: Ryan Brown, PhD
Phone: 212-263-0380
New York University School of Medicine NYU School of Medicine has a proud history that...
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