Oral Tranexamic Acid and Laser for Treatment of Melasma

Seeking healthy non-smoking male and female volunteers of all skin types of age 18 to 50 with
moderate melasma or severe melasma. Participants will receive up to 5 monthly laser
treatments to half the face and need to take a pill twice a day for 4 months. Follow up
visits are required 1 month, 3 months and 6 months after the final treatment. Compensation of
up to $150 will be provided based on completed visits.

Inclusion Criteria:

Age 18 to 50 Skin types I through VI (all skin types) Moderate or severe melasma

Exclusion Criteria:

Pregnant or nursing women Current use of hormonal birth control medication or any hormonal
therapy Use of topical steroids within 1 month of study enrollment Use of topical
hydroquinone within 3 months of study enrollment History of laser or dermabrasion to the
face within 6 months of study enrollment Regular use of tanning parlors Occupation
involving primarily outdoor activities Current treatment with blood thinning medications
History of thrombosis or thrombophilia History of thromboembolic disease, such as deep vein
thrombosis, pulmonary embolism and/or cerebral thrombosis Family history of thromboembolic
disease History of stroke History of >2 spontaneous abortions History of kidney dysfunction
History of cancer Smoking Significant cardiovascular or respiratory disease (end-stage
congestive heart failure or chronic obstructive pulmonary disease) History of subarachnoid
hemorrhage History of acquired disturbances of color vision Known allergy to tranexamic
acid As per the investigator's discretion, any physical or mental condition which might
make it unsafe for the subject to participate in this study