Medical Therapy of Prostatic Symptoms

The Medical Therapy of Prostatic Symptoms (MTOPS) is a clinical research study sponsored by
the National Institutes of Health (NIH). The study will test whether the oral drugs
finasteride (Proscar) and doxazosin (Cardura), alone or together, can delay or prevent
further worsening of symptoms in men with Benign Prostatic Hyperplasia (BPH).

MTOPS is the largest and longest study to simultaneously test whether these drugs can delay
or prevent the clinical progression (symptom worsening) of BPH. Seventeen U.S. medical
centers recruited 2,931 men diagnosed with symptomatic BPH between December 1995 and March
1998. Study doctors will continue to follow these men through November 2001 on a quarterly
basis. In addition to the clinical progression of BPH, MTOPS will include evaluations of
prostate volume by ultrasound, prostate biopsies among a subgroup of volunteers, and quality
of life.