Using Serious Games to Improve Social Skills in Autism

The investigators will conduct a small-scale randomized control trial comparing the
intervention game to an placebo control game, and will assess outcomes at multiple time
points (pre-, post-, 6-month follow-up). These outcomes will include a wide range of
behaviors that are measured along a continuum from controlled lab-based tasks to real-world
social interactions between dyads. The aims are evaluating 1) changes in the target
mechanisms (social attention to faces, sensitivity to eye gaze cues) for the intervention
relative to active control group, 2) engagement of intermediate mechanisms, including
face-processing behaviors and real-world social communication behaviors, and 3) the relation
between engagement of the target and intermediate mechanisms and symptom outcomes. Evidence
of changes in autism social symptoms resulting from changing visual attention to faces and/or
improved ability to understand eye gaze cues will provide clear evidence to inform a "go"
decision about the therapeutic target for further clinical development.

Inclusion Criteria:

1. parent/caregiver of an adolescent with a diagnosis of autism spectrum disorder (ASD),

2. parent/caregiver and adolescent with ASD both native English speakers,

3. adolescent with ASD aged between 10-18 years at pre-test,

4. adolescent has normal vision and hearing with correction as reported by caregiver,

5. adolescent is able to use a computer for the purposes of game play,

6. adolescent scores < 80% correct (i.e., 0.5 SD less than Mean of typically developing
adolescents) on online eye gaze screening task,

7. ASD diagnosis of adolescent confirmed in lab via the Autism Diagnostic Observation
Schedule (ADOS-2);

8. Full Scale IQ of adolescent determined to be between 70-130;

9. reading ability of adolescent determined to be at least a 2nd grade level;

10. adolescent is capable of cooperating with testing;

11. parent/caregiver and adolescent both consent/assent to participate in the research.

Exclusion Criteria:

1. having seizures within the previous two years

2. no stable internet connection in the home

3. refusing to consent/assent to take part in the research

4. 18 and have a legal guardian, which prohibits them from legally consenting for
themselves

5. 18 and cannot understand the consent as indicated by failing a quiz prior to signing
the consent.