Light Treatment for Sleep/Wake Disturbances in Alzheimer's Disease
| Status: | Completed |
|---|---|
| Conditions: | Alzheimer Disease, Insomnia Sleep Studies |
| Therapuetic Areas: | Neurology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 55 - 100 |
| Updated: | 10/5/2018 |
| Start Date: | September 2004 |
| End Date: | December 2010 |
The aim of this study is to demonstrate the efficacy of timed exposure to bright light for
the treatment of disturbed nighttime sleep and daytime wake in community-dwelling dementia
patients and their caregivers, and to determine if there are genetic relationships between
memory problems and sleep problems
the treatment of disturbed nighttime sleep and daytime wake in community-dwelling dementia
patients and their caregivers, and to determine if there are genetic relationships between
memory problems and sleep problems
1. Efficacy: Up to 4 weeks of morning bright light exposure will be more efficacious than
morning dim light in consolidating nighttime sleep as assessed by actigraphy.
2. Predictors of response: We expect the primary predictor of treatment response will be
initial MMSE score. Secondary predictors include baseline sleep/wake and circadian
parameters and age.
3. Effectiveness: Bright light treatment will be more effective than dim light in improving
quality of life.
4. An understanding of some of the genetic markers of memory and/or sleep problems.
morning dim light in consolidating nighttime sleep as assessed by actigraphy.
2. Predictors of response: We expect the primary predictor of treatment response will be
initial MMSE score. Secondary predictors include baseline sleep/wake and circadian
parameters and age.
3. Effectiveness: Bright light treatment will be more effective than dim light in improving
quality of life.
4. An understanding of some of the genetic markers of memory and/or sleep problems.
Inclusion Criteria:Alzheimer's Disease Patients:
- Stanford Alzheimer's Disease Core Center member or potential member, with diagnostic
criteria met for probable AD, living with caregiver willing to participate in the
protocol
- Non-institutionalized
Caregivers:
-- Living in home of AD patient and willing to participate in protocol
Exclusion Criteria:Alzheimer's Disease Patients:
- History of manic or bipolar disorder
- Prior bright light treatment
- Irregular or non-24 hour sleep/wake cycle
- Positive result on multi-staged RLS/PLMD
- Medical/Ophthalmologic Exclusions
- RDI >20 on overnight EdenTrace® recording
Caregivers:
- History of manic or bipolar disorder
- Medical/Ophthalmologic Exclusions
We found this trial at
1
site
VA Palo Alto Health Care System The VA Palo Alto Health Care System (VAPAHCS) consists...
Click here to add this to my saved trials
