Safety and Efficacy of Vicriviroc (MK-7690) in Combination With Pembrolizumab (MK-3475) in Participants With Advanced/Metastatic Microsatellite Stable (MSS) Colorectal Cancer (CRC) (MK-7690-046)

Inclusion Criteria:

- Have a histologically proven locally advanced unresectable or metastatic CRC.

- Have locally confirmed MSS CRC.

- Have been previously treated with standard therapies, which must include
fluoropyrimidine, oxaliplatin, and irinotecan, and have received, been intolerant to,
or been ineligible for all treatment known to confer clinical benefit.

- Have measurable disease per RECIST 1.1 as assessed by the local site
investigator/radiology.

- Have provided archival tumor tissue sample or newly obtained core or excisional biopsy
of a tumor lesion not previously irradiated.

- Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 within
7 days of starting study intervention.

- Male participants must agree to use contraception and refrain from donating sperm for
at least 120 days after the last dose of study intervention.

- Female participants must be not pregnant and not breastfeeding. Further, a female
participant must either not be a woman of childbearing potential (WOCBP) or, if a
WOCBP, agree to use contraception during the treatment period and for at least 120
days after the last dose of study intervention.

- Have adequate organ function.

Exclusion Criteria:

- Have a known additional malignancy that is progressing or has required active
treatment within the past 2 years. Participants with basal cell carcinoma of the skin,
squamous cell carcinoma of the skin, or carcinoma in situ (e.g., breast carcinoma,
cervical cancer in situ) that have undergone potentially curative therapy are not
excluded.

- Have known active central nervous system (CNS) metastases and/or carcinomatous
meningitis.

- Have severe hypersensitivity reaction to treatment with any monoclonal antibody or
components of the study interventions.

- Have an active autoimmune disease requiring systemic treatment in the past 2 years,
except vitiligo or resolved childhood asthma/atopy.

- Have a history of vasculitis.

- Have an active infection requiring systemic therapy.

- Have symptomatic ascites or pleural effusion.

- Have interstitial lung disease requiring oral or IV glucocorticoids.

- Have a history of pneumonitis (noninfectious) that required steroids, or has current
pneumonitis.

- Have a known history of HIV infection.

- Have a known history of hepatitis B or known active hepatitis C virus infection.

- Have a known history of active tuberculosis (TB; Bacillus tuberculosis).

- Have a history or current evidence of any condition, therapy, or laboratory
abnormality that might confound the results of the study, interfere with the
participant's participation for the full duration of the study, make administration of
the study interventions hazardous, or make it difficult to monitor adverse events.

- Have a known psychiatric or substance abuse disorder that would interfere with the
participant's ability to cooperate with study requirements.

- Are pregnant or breastfeeding or expecting to conceive or father children within the
projected duration of the study, starting with the Screening Visit through 120 days
after the last dose of study intervention.

- Are a WOCBP who has a positive urine pregnancy test within 72 hours before
randomization or treatment allocation.

- Have undergone major surgery and have not recovered adequately from any toxicity
and/or complications from the intervention before starting study intervention.

- Have a seizure disorder requiring ongoing antiseizure therapy or with any condition
that, in the judgment of the investigator, is likely to increase the risk of seizure
(e.g., CNS malignancy or toxoplasmosis).

- Have known gastrointestinal (GI) disease such as esophageal, gastric, or duodenal
ulceration or inflammatory bowel disease, or history of GI surgery.

- Are using any drug (therapeutic or recreational), or withdrawal thereof, that poses an
increased risk of convulsions.

- Have had an allogeneic tissue/solid organ transplant.

- Have received prior therapy with vicriviroc or other CCR5 antagonist (e.g., maraviroc)
or have received prior therapy with an anti-PD-1, anti-PD-L1, or anti PD-L2 agent.

- Have been treated with an agent directed to another stimulatory or co-inhibitory
T-cell receptor (e.g., cytotoxic T-lymphocyte-associated protein 4 [CTLA-4], OX 40,
CD137).

- Have received prior systemic anticancer therapy, including investigational agents, or
has used an investigational device within 28 days before the first dose of study
intervention.

- Have received prior radiotherapy (not to target lesions) within 2 weeks of start of
study intervention.

- Are expected to require any other form of antineoplastic therapy while on study.

- Have a diagnosis of immunodeficiency, is receiving chronic systemic steroid therapy in
excess of replacement doses (prednisone ≤10 mg/day is acceptable), or is taking any
other form of immunosuppressive medication within 7 days before the first dose of the
study intervention.

- Have received a live-virus vaccine within 30 days before the first dose of the study
intervention.

- Are currently participating in or have participated in a study of an investigational
agent, or have used an investigational device within 28 days before the first dose of
study intervention.