Resting Energy Expenditure in Patients With Cystic Fibrosis: A Pilot Study
| Status: | Recruiting |
|---|---|
| Conditions: | Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 6 - 99 |
| Updated: | 10/13/2018 |
| Start Date: | October 10, 2018 |
| End Date: | October 8, 2019 |
| Contact: | Amanda Dye, MD |
| Email: | asdye@hsc.wvu.edu |
| Phone: | 304-388-1552 |
Cystic fibrosis is an inherited disorder that causes severe damage to the lungs, digestive
system, and other organs in the body. Individuals with cystic fibrosis often have poor weight
gain and growth that can negatively impact health further by worsening lung function.
Additionally, persons with the disease typically need more than the usual calories on a daily
basis.
Most institutions estimate these patients' caloric needs using weight, age, and sex based
mathematical formulae. However, numerous studies show that use of these formulae often yields
inaccurate caloric values. Use of indirect calorimetry may give more accurate estimates of
caloric needs in patients with cystic fibrosis.
The aim of our study is to assess the accuracy of caloric estimates generated using one such
widely used mathematical formula, the Harris-Benedict equation, and to compare this calorie
value with that obtained from indirect calorimetry testing in pediatric and adult patients
with cystic fibrosis.
Study investigators will use the newly calculated caloric requirements in dietary counseling.
Changes in weight and lung function after 3 months will be compared to participants'
historical changes.
system, and other organs in the body. Individuals with cystic fibrosis often have poor weight
gain and growth that can negatively impact health further by worsening lung function.
Additionally, persons with the disease typically need more than the usual calories on a daily
basis.
Most institutions estimate these patients' caloric needs using weight, age, and sex based
mathematical formulae. However, numerous studies show that use of these formulae often yields
inaccurate caloric values. Use of indirect calorimetry may give more accurate estimates of
caloric needs in patients with cystic fibrosis.
The aim of our study is to assess the accuracy of caloric estimates generated using one such
widely used mathematical formula, the Harris-Benedict equation, and to compare this calorie
value with that obtained from indirect calorimetry testing in pediatric and adult patients
with cystic fibrosis.
Study investigators will use the newly calculated caloric requirements in dietary counseling.
Changes in weight and lung function after 3 months will be compared to participants'
historical changes.
Inclusion Criteria:
- Patients with cystic fibrosis who are equal to or older than six years of age
presenting to West Virginia University-Charleston Cystic Fibrosis Center for their
regularly scheduled appointments/check-ups.
- Patients at the Cystic Fibrosis Center for at least 12 months.
Exclusion Criteria:
- Patients with cystic fibrosis who are younger than 6 years of age.
- Patients without cystic fibrosis.
- Patients currently pregnant.
- Cystic fibrosis patients with significant disease exacerbation (such as needing oral
steroids or antibiotics, hospital admission within 30 days) or patients who currently
having the flu or a serious upper respiratory infection.
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