Family History Study of Alcohol Consumption Using Memantine
| Status: | Completed |
|---|---|
| Conditions: | Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 21 - 50 |
| Updated: | 7/13/2018 |
| Start Date: | June 2006 |
| End Date: | August 2011 |
NMDA Antagonist Efficacy in Reducing Human Alcohol Consumption: Impact of Family History
The purpose of this study is to evaluate the effects of the study medication, memantine
(placebo, 20 mg or 40 mg/day) on alcohol drinking behavior in a laboratory setting in which
participants are given an initial drink of alcohol followed by the choice to drink up to 12
more drinks over a three-hour period. We hypothesize that memantine will reduce craving and
number of drinks consumed prior to and after exposure to the initial drink of alcohol and
during the three hour drinking period. We will also evaluate the influence of family history
of alcoholism on the efficacy of memantine in reducing alcohol drinking behavior.
(placebo, 20 mg or 40 mg/day) on alcohol drinking behavior in a laboratory setting in which
participants are given an initial drink of alcohol followed by the choice to drink up to 12
more drinks over a three-hour period. We hypothesize that memantine will reduce craving and
number of drinks consumed prior to and after exposure to the initial drink of alcohol and
during the three hour drinking period. We will also evaluate the influence of family history
of alcoholism on the efficacy of memantine in reducing alcohol drinking behavior.
Inclusion Criteria:
- Ages 21-50
- Able to read English at 6th grade level or higher and to complete study evaluations
- Regular alcohol drinker
Exclusion Criteria:
- Individuals who are seeking alcohol treatment
- Medical conditions that would contraindicate the use of memantine
- Regular use of other substances
We found this trial at
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