Observational Hemodynamic Monitoring During LVAD Implantation Among Individuals With Advanced Heart Failure

Inclusion Criteria:

- individuals ≥ 18 years of age with severe heart failure (HF) and who have been
approved by the advanced HF selection committee for LVAD implantation.

Exclusion Criteria:

- Patients with pre-existing right ventricular (RV) dysfunction/failure, defined as:

1. Imaging evidence of moderate-severe RV dysfunction on echocardiography

2. Hemodynamic evidence of RV dysfunction with:

- a right-atrial pressure (RAP): pulmonary capillary wedge pressure (PCWP)
ratio of ≥ 0.67 (note: this index compares pressures on the right [RAP] and
left [PCWP] side of the heart;

- an RAP/PCWP ratio ≥ 0.67 provides hemodynamic evidence of RV dysfunction.

3. Clinical evidence of preexisting RV dysfunction, as indicated by significant
(3-4+ peripheral edema) and/or elevated jugular venous pressures on clinical
examination.

4. Patients with end-stage renal disease requiring hemodialysis

5. Patients requiring temporary hemodynamic support prior to LVAD implantation with
temporary LVADs, and/or veno-arterial extracorporeal membrane oxygenators
("ECMO").

6. Planned concurrent implantation of right ventricular assist device