Eating Behavior in Adolescents



Status:Completed
Conditions:Obesity Weight Loss, Psychiatric
Therapuetic Areas:Endocrinology, Psychiatry / Psychology
Healthy:No
Age Range:13 - 17
Updated:10/8/2017
Start Date:March 5, 2008
End Date:September 8, 2015

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This study will explore the eating habits of adolescents and determine if eating behavior is
linked to genetics.

Healthy adolescents between 13 and 17 years of age may be eligible for this study. Candidates
come to the NIH Clinical Center at 8:00 AM to be screened with the following:

- Medical history and brief physical examination, including height, weight, and body fat
measurements. Body fat is measured using a device called a Bod Pod. The adolescent sits
inside the device for about 5 minutes and the machine determines body fat by measuring
air movement. The adolescent must wear a tight-fitting swimsuit for this test.

- Urine test to look for sugar or protein in the urine and to test for pregnancy in
females.

- Blood tests for routine chemistries and for gene studies related to eating behaviors.

- Questionnaires and interviews about the adolescent s general health and eating habits.

- Acclimatization to test meal conditions for the study. The adolescent is given a
breakfast shake to drink.

Participants come to the NIH Clinical Center at 10:30 AM for laboratory meal testing. At this
visit, the adolescent does the following:

- Eats food from a buffet of everyday foods that most kids eat.

- Fills out questionnaires.

- Tastes and rates the flavor of a variety of snack foods.

Little is known about the eating behaviors that place adolescents at heightened risk for
overweight. In the proposed study, we aim to investigate the role that eating behaviors and
genes may play in the development of overweight. Participants will be adolescent girls and
boys from a racially/ethnically diverse sample of adolescents from the DC Metro community.
Adolescent eating behavior will be observed during laboratory test meals. Adolescents will be
provided with a large buffet of foods or a standard meal and instructed to eat until you are
no longer hungry. Thirty minutes later, they will taste and rate a variety of highly
palatable snack foods. Blood tests will be conducted to examine genes related to eating
behavior. Assessments also will include affective states, degree of hunger, degree of
fullness, body image satisfaction, disordered eating attitudes and behaviors, and measures of
interpersonal interactions.

- INCLUSION CRITERIA:

Volunteers will qualify for participation in the study if they meet the following criteria:

1. Age 13-17 years.

2. Good general health as indicated by medical history and physical examination.

3. Negative urine glucose and normal electrolytes, hepatic, and thyroid function.

4. For the fMRI portion only: right handedness (required for standardization of
responses).

5. For the fMRI portion only: female.

6. For the fMRI portion only: overweight (BMI greater than or equal to 85th
percentile for age and sex).

EXCLUSION CRITERIA:

Volunteers will be excluded if they have any of the following:

1. Medical problem likely to affect caloric intake.

2. History of any condition including psychiatric disorders in either child or their
responsible parent that in the opinion of the investigators would impede competence to
sign consent, interfere with adherence to procedures, or possibly hinder completion of
the study.

3. Pregnancy.

4. Use of medication likely to affect caloric intake.

5. History of significant neurological injury or insult.

6. For the fMRI portion only: braces (or other metal) that would interfere with the
fMRI procedure.

7. For the fMRI portion only: non-native English speakers (required for
standardization of responses).
We found this trial at
1
site
9000 Rockville Pike
Bethesda, Maryland 20892
?
mi
from
Bethesda, MD
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