Neuroimaging of Pain: Changes in Regional Brain Functioning Associated With Amplified Pain and Intensive Treatment
| Status: | Enrolling by invitation |
|---|---|
| Healthy: | No |
| Age Range: | 13 - 19 |
| Updated: | 10/17/2018 |
| Start Date: | July 9, 2018 |
| End Date: | December 2019 |
The proposed study will examine how intensive interdisciplinary pain treatment (IIPT,
specifically the Rehabilitation for Amplified Pain Syndrome, or RAPS, program at Children's
Mercy Hospital) impacts neurofunctional mechanisms of emotional and physical pain processing
in patients. There has been recent interest in characterizing the brain regions responsible
for processing pain (Wager et al., 2013), but little research has included youth. A better
understanding of the physiological mechanisms of pain can lead to better treatment outcomes.
specifically the Rehabilitation for Amplified Pain Syndrome, or RAPS, program at Children's
Mercy Hospital) impacts neurofunctional mechanisms of emotional and physical pain processing
in patients. There has been recent interest in characterizing the brain regions responsible
for processing pain (Wager et al., 2013), but little research has included youth. A better
understanding of the physiological mechanisms of pain can lead to better treatment outcomes.
Youth will be scanned before or during the first week of participation in the Rehabilitation
for Amplified Pain Syndrome (RAPS) program, and a second time near or just after program
completion (typically 3-5 weeks later). One functional MRI task will involve passive viewing
of emotional and pain-related images including some that have been widely used in previous
neuroimaging research (e.g., the International Affective Picture Set, Human Facial
Expressions; alternating positive and negative affect/valence). The other functional MRI
task, will involve systematic external application of somatosensory stimulation (pressure) to
the hand in alternating blocks. The entire imaging procedure will take approximately an hour.
MRI technicians and/or study staff will administer the scanning protocol. Study team will be
responsible for the systematic external application of sensory input.
for Amplified Pain Syndrome (RAPS) program, and a second time near or just after program
completion (typically 3-5 weeks later). One functional MRI task will involve passive viewing
of emotional and pain-related images including some that have been widely used in previous
neuroimaging research (e.g., the International Affective Picture Set, Human Facial
Expressions; alternating positive and negative affect/valence). The other functional MRI
task, will involve systematic external application of somatosensory stimulation (pressure) to
the hand in alternating blocks. The entire imaging procedure will take approximately an hour.
MRI technicians and/or study staff will administer the scanning protocol. Study team will be
responsible for the systematic external application of sensory input.
Inclusion Criteria:
- Age 13 to 19
- Admitted to the RAPS program for intensive treatment
Exclusion Criteria:
- Inability to participate in imaging due to developmental delay
- Inability or unwillingness to be still during imaging procedures
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