Behavioral Weight Loss and Stigma Reduction

Inclusion Criteria:

- Eligible participants will be men and women ages 18 years and older.

- Participants must have obesity, defined as a BMI ≥ 30 kg/m2 or ≥ 27 kg/m2 with an
obesity-related comorbidity.

o Obesity-related comorbidities (which confer added CVD risk) will include:

- coronary heart disease;

- other atherosclerotic disease;

- sleep apnea;

- hypercholesteremia (i.e., high cholesterol, as diagnosed by doctor and/or if taking
medication to lower cholesterol);

- and components of the metabolic syndrome, including hypertension (SBP ≥130, DBP ≥80 mm
Hg, diagnosed by doctor and/or if taking anti-hypertensive medication); fasting blood
glucose of 100-125 mg/dL (or prediabetes, diagnosed by doctor),; low HDL cholesterol
(<40 mg/dL in men, <50 mg/dL in women), elevated triglycerides (>150 mg/dL, i.e.,
dyslipidemia diagnosed by doctor or taking medication to treat dyslipidemia), or
elevated waist circumference (≥40 in for men, ≥35 in for women),.

- Eligible participants must also report a history of experiencing weight bias as
assessed by self-report questionnaire and in-person interview, and have elevated
levels of WBI as indicated by an average score of 4 (midpoint) or above on the Weight
Bias Internalization Scale (WBIS) and by in-person interview.

- Participants must be seeking weight loss.

- If currently taking medications, dosages must be stable for at least 3 months.

- Participants will be eligible to participate if they exhibit mild to moderate severity
of depression, anxiety, or binge eating disorder, as determined by the behavioral
evaluation and the screening measures (Beck Depression Inventory-II and Questionnaire
for Eating and Weight Patterns; see below for details). Elevated WBIS scores are often
associated with these variables.

- Participants taking anti-depressant medication will be eligible if their dose has been
stable for a minimum of 3 months.

Eligible female patients will be:

- non-pregnant and non-lactating

- surgically sterile or postmenopausal, or they will agree to continue to use a method
of birth control during the study

Participants must:

- have a PCP who is responsible for providing routine care

- have reliable telephone service and/or email access with which to be in contact with
the study team

- understand and be willing to comply with all study-related procedures and agree to
participate in the study by giving written informed consent

Exclusion Criteria:

Applicants will be excluded if they have:

- a diagnosis of type I or II diabetes (for type II diabetes, blood glucose ≥126 mg/dL
or A1C ≥6.5);

- uncontrolled hypertension (blood pressure ≥ 160/100 mm Hg);

- experienced a cardiovascular event (e.g., stroke, myocardial infarction) in the last
12 months;

- lost and maintained ≥ 5% of their initial weight in the last 3 months or ≥ 10% in the
past 2 years;

- or have participated in individual or group psychotherapy related to weight in the
last 3 months (due to the potentially confounding effects of receiving a simultaneous
cognitive-behavioral intervention).

o Participants who have recently received or are currently receiving therapy for a
pre-existing mental health issue unrelated to weight (e.g., psychotherapy for
depression or anxiety, or marriage, grief, or career counseling) may be eligible if
the therapy is deemed by the Principal Investigator to be unlikely to affect weight,
eating habits, or physical activity.

- Applicants with severe symptoms of mood (BDI-II score ≥ 29), anxiety, or binge eating
disorder, and any severity of thought or substance use disorders will not be accepted
into the study, as these symptoms may interfere with individuals' ability to adhere to
a weight loss program.

o Clinician judgment will be used to determine severity of mood disorder symptoms
independent from obesity-related concerns and complications (e.g., fatigue), and
decisions about applicants' eligibility based on psychiatric symptoms will fall within
the Principal Investigator's discretion.

- Individuals with bulimia nervosa will not be eligible to participate, because weight
loss may be contraindicated.

- Applicants with current, active suicidal ideation, and/or a suicide attempt within the
past year will be excluded from the study and referred to psychiatric treatment
facilities in the greater Philadelphia area.

- Applicants will not be eligible if they have a history of bariatric surgery.

- Women who are nursing, pregnant, or planning to become pregnant in the next 16 months
are not eligible to participate.

- Applicants who report obtaining 150 minutes or more of structured physical activity
per week (e.g., 30 minutes 5 days per week) will not be eligible, as they will already
be obtaining the recommended amount of physical activity and may not be able to
further increase their activity as part of the study.