A Study on the Effects of LY2409021 on the Electrical Impulses of the Heart

This is a 2 part study. Part A is a single-dose study to compare the effects of a meal on
glucose, insulin and QT in healthy participants with and without LY2409021. Part B of this
study is a randomized, 3-period, crossover design, in which participants and investigators
are blinded to placebo and LY2409021, and will assess the electrophysiological effects of a
single supratherapeutic dose of LY2409021 compared to a positive control (moxifloxacin) and
placebo.

Inclusion Criteria:

- are overtly healthy males or females, as determined by medical history and physical
examination

- female participants: women not of child-bearing potential due to surgical
sterilization (hysterectomy alone or at least 6 weeks postsurgical bilateral
oophorectomy with or without hysterectomy or tubal ligation) confirmed by medical
history, or menopause Women with an intact uterus are deemed postmenopausal if they
are >=45 years old, have not taken hormones or oral contraceptives within the last
year, had cessation of menses for at least 1 year, or have had 6 to 12 months of
amenorrhea with follicle-stimulating hormone levels consistent with postmenopausal
state

- have a body mass index (BMI) of 18.5 to 32 kilograms per meter squared (kg/m^2),
inclusive, at screening

- have a fasting blood glucose between 54 to 110 milligrams per deciliter (mg/dL) (3.0
to 6.1 millimoles per liter [mmol/L])

- have a clinically normal screening electrocardiogram (ECG) with a measurable QT
interval as judged by central reader, which allows accurate measurements of QT
interval

- have clinical laboratory test results within normal reference range for the population
or investigator site, or results with acceptable deviations that are judged to be not
clinically significant by the investigator

- have venous access sufficient to allow for blood sampling

- are reliable and willing to make themselves available for the duration of the study
and are willing to follow study procedures

- have normal blood pressure and pulse rate (supine) at screening, or with minor
deviations judged to be acceptable by the investigator

- have given written informed consent approved by Lilly and the ethical review board
(ERB) governing the site

- serum magnesium and potassium equal to or above the lower limit of normal

Exclusion Criteria:

- are currently enrolled in or have completed or discontinued within the last 30 days
(from screening) from a clinical trial involving an investigational product; or are
concurrently enrolled in any other type of medical research judged not to be
scientifically or medically compatible with this study

- have known allergies to LY2409021, related compounds or any components of the
formulations, or to moxifloxacin

- are persons who have previously received the investigational product in this study,
have completed or withdrawn from this study or any other study investigating LY2409021

- personal or family history of long QT syndrome

- family history of sudden unexplained death or cardiac death in a family member under
60 years of age

- personal history of unexplained syncope within the last year

- have a history or presence of cardiovascular, respiratory, hepatic, renal,
gastrointestinal, endocrine, hematological, or neurological disorders capable of
significantly altering the absorption, metabolism, or elimination of drugs; of
constituting a risk when taking the study medication; or of interfering with the
interpretation of data

- regularly use known drugs of abuse and/or show positive findings on urinary drug
screening

- show evidence of human immunodeficiency virus (HIV) infection and/or positive human
HIV antibodies

- show evidence of hepatitis C and/or positive hepatitis C antibody

- show evidence of hepatitis B and/or positive hepatitis B surface antigen

- are women with a positive pregnancy test or women who are lactating

- intend to use over-the-counter (including mineral supplements and herbal medicine) or
prescription medication within 7 days prior to dosing

- have donated blood of more than 500 milliliters (mL) within the last month

- have an average weekly alcohol intake that exceeds 21 units per week (males) and 14
units per week (females) (1 unit = 12 ounces [oz] or 360 mL of beer; 5 oz or 150 mL of
wine; 1.5 oz or 45 mL of distilled spirits), or are unwilling to comply with alcohol
restrictions during the study (that is, refrain from alcohol consumption from 24 hours
prior to dosing until the completion of each treatment period and to consume no more
than 2 units of alcohol per day between treatment periods)

- are participants who smoke more than 10 cigarettes per day and/or are unable to abide
by the study restrictions for smoking/tobacco use (that is, refrain from smoking for
approximately 2 hours prior to each ECG timepoint or for a total of approximately 12
hours)

- are participants who are unable to abide by the study restrictions for
caffeine/xanthine use (that is, refrain from consuming caffeine/xanthine containing
drinks and foods [such as coffee, tea, cola, and chocolate] on days on which ECGs are
performed, and maintain consistent consumption habits on all other days of the study)