Study of TRPH-222 in Patients With Relapsed and/or Refractory B-Cell Lymphoma

Inclusion Criteria

- Age ≥ 18 years at the time of signing the informed consent

- Histologically confirmed (2016 WHO lymphoma classification) B-cell NHL that is DLBCL,
FL (including transformed FL), MZL, or MCL

- Relapsed and/or refractory NHL requiring systemic therapy and have failed, are
intolerant to, or are considered ineligible for standard of care anticancer treatments
that are known to be potentially curative. Subjects must not be current candidates for
HSCT. Participants who refuse standard treatments may also be considered provided that
documentation is provided that the subject has been made aware of all therapeutic
options

- Eastern Cooperative Oncology Group (ECOG) status 0-2

Exclusion Criteria

- Presence of a leukemic phase of the lymphoma

- "Double hit" or "triple hit" germinal center B cell lymphoma

- Previous solid organ allograft (except for corneal transplant)

- Peripheral neuropathy > NCI-CTCAE Grade 1

- Significant organ dysfunction that would preclude study participation

- Significant cardiovascular disease such as uncontrolled or symptomatic arrhythmias

- Any other serious active disease or co-morbid medical condition, according to the
Investigator's decision or Medical Monitor, that will substantially increase the risk
associated with the subject's participation in the study