Ultra-High Resolution Optical Coherence Tomography in Detecting Micrometer Sized Early Stage Pancreatic Cancer in Participants With Pancreatic Cancer

PRIMARY OBJECTIVES:

I. To evaluate the using of optical coherence tomography (OCT) to diagnose pancreatic cancer
arising in the setting of intraductal papillary mucinous neoplasms (IPMN) using the resected
pancreatic specimen.

II. To correlate OCT imaging diagnosis with histologic findings in the human pancreatic duct.

IPMN is a premalignant lesions arising in the pancreas. Typically, IPMNs are identified
incidentally on imaging performed for other reason or related to vague abdominal pain or
gastrointestinal complaints. In terms of IPMN, invasive cancer can be found in this setting
between 20 to 50% of the time[7] Therefore, if a patient is diagnosed with IPMN, especially
main duct type, the general recommendation is to undergo resection. We propose to assess the
duct of the pancreatic specimen after resection to identify evidence of invasive malignancy
by OCT imaging. Afterwards, the specimen will be undergoing histopathologic assessment using
standard protocols. Our hypothesis is that OCT will accurately identify pancreatic cancer in
resected pancreatic specimen. The assessment with OCT is non-invasive and will not harm to
change the specimen prior to going to pathology for standard review. Future studies will then
focus on using this imaging technique in vivo to endoscopically identify early stage
pancreatic cancer.

Inclusion Criteria:

- Immediate surgery cohort: Adult patients with pancreatic cancer or IPMN

- Immediate surgery cohort: Informed consent will be obtained

- Adult patients undergoing pancreatic resection for a presumed IPMN

Exclusion Criteria:

- Pregnant