The Effect of 10-Week Exercise Training on Children With Asthma
| Status: | Recruiting |
|---|---|
| Conditions: | Asthma |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 8 - 35 |
| Updated: | 10/25/2018 |
| Start Date: | October 10, 2013 |
| End Date: | October 17, 2020 |
| Contact: | Fadia Haddad, Ph.D. |
| Email: | fhaddad@uci.edu |
| Phone: | (949) 824-6810 |
Exercise Training in Children and Adults: Mechanisms of Allaying Inflammation in Asthma
The goal of this research is to determine whether 10-weeks of exercise training can benefit
asthmatic children and young adults with a history of exercise-induced bronchoconstriction
(EIB). The investigators will also study an exciting newly discovered aspect of gene
expression regulation in the white blood cells known as epigenetics: a process that takes
place when genomic changes happen as a result of exposure to the environment. This study is
based on emerging exciting new data from this and other laboratories demonstrating that (a)
white blood cells play an important role in bronchoconstriction in children, (b) gene and
cytokine expression in circulating white blood cells are abnormal in asthma and (c) brief
exercise may change genomic and inflammatory- profiles of these cells.Physical activity is an
essential component of growth and health in children, thus, this research will lead to
improved clinical uses of exercise as preventive and adjunctive therapy in the current
epidemic of childhood asthma
asthmatic children and young adults with a history of exercise-induced bronchoconstriction
(EIB). The investigators will also study an exciting newly discovered aspect of gene
expression regulation in the white blood cells known as epigenetics: a process that takes
place when genomic changes happen as a result of exposure to the environment. This study is
based on emerging exciting new data from this and other laboratories demonstrating that (a)
white blood cells play an important role in bronchoconstriction in children, (b) gene and
cytokine expression in circulating white blood cells are abnormal in asthma and (c) brief
exercise may change genomic and inflammatory- profiles of these cells.Physical activity is an
essential component of growth and health in children, thus, this research will lead to
improved clinical uses of exercise as preventive and adjunctive therapy in the current
epidemic of childhood asthma
Inclusion Criteria:
- Good health
- Physical activity
- No evidence of disease or disability
- Diagnosed with persistent asthma (asthma subjects)
- BMI<95 percentile
Exclusion Criteria:
- Use of illegal drugs or alcohol
- Very high physical fitness
- Pregnancy
- More than two asthma attack per week (asthma subjects)
We found this trial at
1
site
Irvine, California 92697
Phone: 949-824-6810
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