Gene Expression and Biomarker Profiling of Keloid Skin



Status:Recruiting
Conditions:Dermatology
Therapuetic Areas:Dermatology / Plastic Surgery
Healthy:No
Age Range:18 - Any
Updated:2/20/2019
Start Date:September 11, 2017
End Date:December 2019
Contact:Yasmeen Ali
Email:yasmeen.ali@northwestern.edu
Phone:3125035906

Use our guide to learn which trials are right for you!

Trial Summary
Trial Overview
Inclusion Criteria
This study aims to examine both the genetic profile and the biomarkers implicated in keloid
scar formation.

Hypothesis:

1. Differences in the genetic profiles of lesional and non-lesional skin contribute a given
population's propensity to develop keloids

2. Differences in biomolecules expressed in subjects with and without keloids can help
predict keloid occurrence and severity

3. Biomarker analysis will provide useful insights for future targeted therapies for keloid
scars

Objectives:

1. Determine gene expression profiles of keloid scar tissue using samples collected
longitudinally

2. Define and compare the molecular biomarkers of keloid scars in keloid (lesional) and
non-lesional skin biopsies and serum samples from adult subjects

Inclusion Criteria:

- Patient with an untreated keloid scar or a patient with a keloid scar that has not had
treatment for at least 6 months before time of enrollment

- Patients without keloids coming into the dermatology clinic for a keloid unrelated
issue (Group 5 only)

Exclusion Criteria:

- Patients who have had treatment of their keloid scar within 6 months of date of
enrollment
We found this trial at
1
site
Northwestern University, Feinberg School of Medicine, Department of Dermatology
Chicago, Illinois 60611
?
mi
from
Chicago, IL
Click here to add this to my saved trials